نتایج جستجو برای: vaca c

تعداد نتایج: 1057856  

Journal: :Journal of clinical pathology 1998
T Shimoyama T Yoshimura T Mikami S Fukuda J E Crabtree A Munakata

AIM To examine the vacA genotypes of Helicobacter pylori strains in Japan and to define whether any specific genotype was associated with gastric cancer. METHODS The allelic variation of vacA gene was studied using a recently introduced polymerase chain reaction based vacA genotyping system. RESULTS 80 H pylori strains were isolated from gastric biopsies of 40 patients with gastric cancer a...

2017
Alexander Link Cosima Langner Wiebke Schirrmeister Wiebke Habendorf Jochen Weigt Marino Venerito Ina Tammer Dirk Schlüter Philipp Schlaermann Thomas F Meyer Thomas Wex Peter Malfertheiner

AIM To evaluate the frequency of Helicobacter pylori (H. pylori) CagA antibodies in H. pylori infected subjects and to identify potential histopathological and bacterial factors related to H. pylori CagA-immune response. METHODS Systematic data to H. pylori isolates, blood samples, gastric biopsies for histological and molecular analyses were available from 99 prospectively recruited subjects...

2017
Dan Wang Qiuping Li Yuehua Gong Yuan Yuan

BACKGROUND H. pylori virulence factors, especially vacA and cagA are important in gastroduodenal disease pathogenesis and affect cure rates. This meta-analysis aimed to clarify the association between vacA or cagA status and eradication outcome of H. pylori infection. METHODS A literature search was performed using electronic databases to identify studies. Twenty-six prospective studies were ...

2018
Josefina Atrisco-Morales Verónica I. Martínez-Santos Adolfo Román-Román Judit Alarcón-Millán José De Sampedro-Reyes Iván Cruz-del Carmen Dinorah N. Martínez-Carrillo Gloria Fernández-Tilapa

PURPOSE Virulent genotypes of Helicobacter pylori vacA s1m1/cagA+/babA2+ have been associated with severe gastric diseases. VacA, CagA and BabA are polymorphic proteins, and their association with the disease is allele-dependent. The aims of this work were: (i) to determine the prevalence of H. pylori by type of chronic gastritis; (ii) to describe the frequency of cagA, babA2 and vacA genotypes...

Journal: :The Journal of infectious diseases 2009
Biguang Tuo Penghong Song Guorong Wen Xaver Sewald Bettina Gebert-Vogl Rainer Haas Michael Manns Ursula Seidler

BACKGROUND The pathogenic mechanisms involved in Helicobacter pylori-induced duodenal mucosal injury are incompletely understood. In the present study, we sought to investigate the effect of H. pylori vacuolating cytotoxin (VacA) on duodenal mucosal bicarbonate (HCO3-) secretion. METHODS Concentrated bacterial culture supernatants from an H. pylori wild-type strain producing VacA with s1/m1 g...

Journal: :Memorias do Instituto Oswaldo Cruz 2005
Luisa Caricio Martins Tereza Cristina de Oliveira Corvelo Samia Demachki Marialva T F Araujo Mônica Baraúna Assumpção Simone Cristina Araujo Jucá Vilar Felipe Bonfim Freitas Hivana Patricia Melo Barbosa Amanda Alves Fecury Renata Kelly Costa do Amaral Sidney Emanuel Batista Dos Santos

We have examined the prevalence of gene cagA and vacA alleles in 129 patients, 69 with gastritis and 60 with peptic ulcer diseases from North Brazil and their relation with histopathological data. vacA and cagA genotype were determined by polymerase chain reaction. Hematoxylin-eosin staining was used for histological diagnosis. 96.6% of the patients were colonized by Helicobacter pylori strains...

Journal: :Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 2009
Khalid Mubarak Bindayna Ali Al Mahmeed

BACKGROUND The vacuolating cytotoxin and the cytotoxinassociated protein, encoded by vacA and cagA, respectively, are important virulence determinants of Helicobacter pylori. OBJECTIVE The aim of this study was to perform vacA genotyping and evaluate its association with cagA genotype and clinical outcome. METHODS One hundred and twenty H. pylori strains were isolated from dyspeptic patient...

  Background :The cag pathogenicity island includes a number of genes, including cytotoxin-associated protein A (cagA) and vacuolatingcytotoxin (vacA) genotypes, which are associated with bacterial virulence. Although the role of cagA and vacA in the virulence of Helicobacter pylori (H. pylori) is well-established in epidemiological studies, the relationship between the cagA and vacA genotypes ...

2015
Hamid Pajavand Amirhooshang Alvandi Parviz Mohajeri Somaye Bakhtyari Homayoon Bashiri Behnam Kalali Markus Gerhard Farid Najafi Ramin Abiri

BACKGROUND Helicobacter pylori infection and related diseases outcome are mediated by a complex interplay between bacterial, host and environmental factors. Several distinct virulence factors of H. pylori have been shown to be associated with different clinical outcomes. Here we focused on vacA and cagA genotypes of H. pylori strains isolated from patients with gastric disorder. OBJECTIVES Th...

Journal: :Gut 2000
P Y Zheng J Hua K G Yeoh B Ho

BACKGROUND Studies in Western populations suggest that cagA, iceA, and vacA gene status in Helicobacter pylori isolates is associated with increased virulence and peptic ulcer disease. AIM To investigate the relationship between peptic ulcer and expression of Lewis (Le) antigens as well as cagA, iceA, and vacA in H pylori isolates in Singapore. METHODS Expression of Le antigens in H pylori ...

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