In two separate experiments 10 healthy men each were exposed at rest in an exposure chamber to about 200 ppm toluene in the air. Hippuric acid, o-, m-, p-cresol, and phenol in urine were detected by capillary gas chromatography at the beginning and at the end of exposure, and at variable times after the cessation of exposure. In addition toluene in blood was determined at the same intervals. Th...

Previous studies from this laboratory have shown that p-aminohippuric acid is formed from p-aminobenzoic acid and glycine by liver slices (1) and homogenates under aerobic conditions, or anaerobically with adenosinetriphosphate (ATP) as the source of energy (2, 3). Similar observations on the synthesis of hippuric acid have been briefly reported (4). These studies suggested the format,ion of a ...

Objectives-To clarify the relation between the genetic polymorphism of ALDH2 (low Km aldehyde dehydrogenase) and toluene metabolism. Methods-The study subjects were 253 toluene workers (192 men and 61 women with an age range of 18-66). The genotypes ofALDH2 were classified by artificial restriction fragment length polymorphism into the homozygous genotype of normal ALDH2 (NN), the homozygous ge...

In the literature one finds comparatively few references to the fate of the benaoic acid derivatives in the animal body, and even some rather conflicting statements regarding several of the corresponding hippuric acids. The object of our work, therefore, was to prepare the o-, m-, and p-chloro-, bromo-, and iodobenzoic acids, and, by feeding these substances to dogs and rabbits, to compare the ...

This study assessed the relationships between ethylbenzene exposure and levels of 8-hydroxydeoxyguanosine (8-OHdG) among spray painters. Sixty-four male workers employed at a large shipyard were recruited for this investigation. Fifteen spray painters exposed to paint, together with two non-exposed groups, namely 19 sandblasting workers and 30 office staffs were selected as the subjects. Person...