Mutagenic effectiveness and efficiency of gamma rays sodium azide and their combination treatments were studied in the genotype of urdben variety T9. The usefulness of any mutagen in plant breeding depends not only on its effectiveness but also upon its efficiency. Mutagenic effectiveness is a measure of the frequency of mutations induced by unit mutagen dose, whereas mutagenic efficiency is me...

Each parallel class of a uniformly resolvable design (URD) contains blocks of only one block size. AURDwith v points andwith block sizes three and fourmeans that at least one parallel class has block size three and at least one has block size four. Danziger [P. Danziger, Uniform restricted resolvable designs with r = 3, ARS Combin. 46 (1997) 161–176] proved that for all v ≡ 12 (mod 24) there ex...

Severe aplastic anemia (SAA) is a life-threatening disorder for which allogeneic hematopoietic stem cell transplantation (HSCT) is the current available curative treatment. HSCT from matched sibling donors (MSDs) is the preferred therapy for children with acquired SAA. For patients who lack MSDs, immunosuppressive therapy (IST) is widely accepted as a first-line treatment before considering HCT...

Artemia larval ribonuclease (Sebastian, J., and Heredia, C. F., (1978) Eur. J. Bichem. 90,405-411) has been purified near homogeneity and its properties were studied. It consists of a single polypeptide chain of 38,000 daltons. It requires a divalent cation for activity. Ca2+ is the most effective among the metals tested. The metal dependence of the activity is biphasic. Maximal activity is obt...

In order to study the mechanism of the irreversible effects of BrdUrd on the differentiation of limb bud mesenchyme to cartilage, the reannealing behavior of DNA obtained from such cells was examined. Cells incubated with [3H]thymidine ([3H]dThd) during days 1 and 2 of culture incorporated label into repetitive, moderately repetitive, and unique classes of DNA. In contrast, when 5-bromo-2'-[3H]...

Uridine-cytidine kinases (UCK) have important roles for the phosphorylation of nucleoside analogs that are being investigated for possible use in chemotherapy of cancer. We have cloned the cDNA of two human UCKs. The approximately 30-kDa proteins, named UCK1 and UCK2, were expressed in Escherichia coli and shown to catalyze the phosphorylation of Urd and Cyd. The enzymes did not phosphorylate d...