Benign melanotic lesions of the vagina are uncommon and only a few cases have been reported in the literature. A 34-year-old woman was referred because of a Vaginal Intraepithelial Neoplasia 1 biopsy result. On the gynecological examination, two different hyperpigmented areas were noted in the vagina. The colposcopic visualization of the cervix and vagina found an aceto-white lesion at the righ...

Neurocutaneous melanosis is a rare neurocutaneous syndrome defi ned by the presence of multiple and /or giant congenital cutaneous nevi and melanocytic deposits in the central nervous system with the infi ltration of leptomeninges. The major medical concern with giant congenital cutaneous nevi is high risk of developing cutaneous melanoma, leptomeningeal melanoma, and neurocutaneous melanosis. ...

Introduction: Bladder melanosis is an extremely rare condition first reported in 1986 and refers to abnormal deposits of melanin in the urothelial bladder cells. Typically, it is considered a benign condition, but it has also been described associated with urothelial carcinoma and melanoma. Its diagnosis may be difficult for most urologists because of its rarity. Case Report: We present the cas...

BACKGROUND Vulvar melanosis is a benign pigmented lesion that may clinically mimic melanoma. Whereas the dermoscopic features of other pigmented skin lesions have been extensively described, little is known about vulvar melanosis. OBSERVATIONS A retrospective dermoscopic study was conducted on 87 lesions with histopathologically proved melanosis. We describe and define, for the first time to ...

n engl j med 368;24 nejm.org june 13, 2013 2303 A 50-year-old woman underwent colonoscopy for rectal bleeding. Her entire colon appeared dark brown and black, a finding consistent with the diagnosis of melanosis coli (Panel A). Random biopsy specimens from the descending colon revealed sheets and clusters of macrophages laden with brownish pigment in the lamina propria (Panel B, arrow). A tiny,...

Sir,?I am referring to a paper 'on p. 172 of the Indian Medical Gazette, April 1944, on 'Syphilitic melanoderma' where ycm state that in Becher and Obermayer no mention is made of syphilis as a cause of melanosis. In my book ' Histologie der Hautkrankheiten' Springer Verlag, Berlin 1925, Vol. I, p. 517, I do mention it and refer to Fourrier and to Unna as describing it as a rare type of the dis...

Metastatic disease is linked to TERT promoter mutations in conjunctival melanomas (CM). Both and ATRX are associated with faulty telomere maintenance. This study aimed determine the prognostic value of loss melanocytic lesions. Eighty-six lesions from Rotterdam Ocular Melanoma Study group were collected. status determined using immunohistochemical staining molecular diagnostics, respectively. N...