In recent years, DNA adenine methyltransferase identification (DamID) has emerged as a powerful tool to profile protein-DNA interaction on a genome-wide scale. While DamID has been primarily combined with microarray analyses, which limits the spatial resolution and full potential of this technique, our group was the first to combine DamID with sequencing (DamID-Seq) for characterizing the bindi...

Corynebacterium ulcerans may cause diphtheria in humans and caseous lymphadenitis in animals. We isolated nontoxigenic tox-bearing C. ulcerans from 13 game animals in Germany. Our results indicate a role for game animals as reservoirs for zoonotic C. ulcerans.

It is widely recognized that either predicting or determining the absorption, distribution, metabolism, excretion and toxicity (ADME/Tox) properties of molecules helps to prevent the failure of some compounds before they reach the clinic. Consequently, there has been considerable research into developing better in silico, in vitro and in vivo methods and models. Toxicogenomics, proteomics, meta...

Early development of the mammalian cerebral cortex proceeds via a sequence of proliferative and differentiative steps from neural stem cells toward neurons and glia. However, how these steps are molecularly orchestrated is still only partially understood. In this issue of The EMBO Journal, Artegiani and colleagues implicate Tox, a HMG-box transcription factor previously known only for its role ...

In the phase 3 KEYNOTE-590 study (NCT03189719), first-line pembrolizumab plus chemotherapy provided statistically significant and clinically meaningful improvement in OS PFS, maintained HRQoL, was associated with a manageable safety profile versus patients locally advanced, unresectable or metastatic esophageal cancer Siewert type 1 gastro-esophageal junction adenocarcinoma. The objective of th...

In silico drug design using virtual screening, absorption, distribution, metabolism and excretion (ADME)/Tox data analysis, automated docking and molecular dynamics simulations for the determination of lead compounds for further in vitro analysis is a cost effective strategy. The present study used this strategy to discover novel lead compounds from an in-house database of Traditional Chinese M...