a general, simple, practical and convenient method has been described for the synthesis of anesthetic drug thiopental using thiourea in the presence of sodium ethoxide. anesthetic drug of thiopental was prepared in two stages; during the first stage, the alkylation of mthyl cyanoacetate was performed which was then to be followed by cyclization. alkylation of methyl cyanoacetate which was perfo...

the aim of this study was to determine the effect of thiopental sodium with that of midazolam-ketamine on relieving agitation after tonsillectomy in children. in a clinical trial, 50 children aged 5-10 years, candidates for tonsillectomy, were randomly divided into two 25-member groups. in the first group, thiopental sodium 5mg/kg/iv, and in the second group combination of midazolam 0.01 mg/kg/...

Results. Significant neuronal death was detected after 30 min (but not 10) of anoxia-aglycaemia (40 (4) vs 14 (5)% of control, P<0.05). At 30 min, phosphorylated ppFAK content was significantly decreasedby anoxic glucose-free conditions (55 (27)%of control, P<0.05). This effectwasmarkedly attenuated by thiopental (10 and 100 mM) and isoflurane (1 and 2%). Under control conditions, thiopental (1...

Objective(s): Development of the nervous system in human and most animals is continued after the birth. Critical role of this period in generation and specialization of the neuronal circuits is confirmed in numerous studies. Any pharmacological intervention in this period may result in structural, functional or behavioral abnormalities. In this study, sodium thiopental a GABA mimetic drug was a...

To the Editor:—In their very interesting study, Loop et al. demonstrate an inhibitory effect of thiopental on nuclear factor B (NFB) activation in T cells. However, we missed some essential background information in the discussion. First, the concentration of thiopental used in this study is much higher than plasma concentrations noted in clinical practice or in other models presenting inhibito...

A gaschromatographic method is presented for the determination of thiopental (and of its metabolite pentobarbital) in cases of severe head injuries treated by induction of therapeutic barbiturate coma. To 1 ml serum the internal standard and saturated ammonium sulphate solution are added. The mixture is extracted by chloroform and the concentrated organic phase is injected into the gaschromatog...

Few studies have dealt with thiopental sodium-induced anaesthetic action and the effect of combining meloxicam (a high plasma protein-bound) in 10–15 day old chicks. First, analgesic median effective dose (ED50) was determined as 35.85 mg/kg, IM by up-and-down routine, while hypnotic ED50 value 34.40 chick model. A sodium injection (18, 36 72 IM) produces a significant dose-responsive chicks, b...