نتایج جستجو برای: t cell proliferation

تعداد نتایج: 2220917  

Journal: :Journal of immunology 2005
William C Kieper Amy Troy J Theodore Burghardt Chris Ramsey Joon Youb Lee Han-Qing Jiang Wolfgang Dummer Hao Shen John J Cebra Charles D Surh

Homeostatic proliferation of naive T cells transferred to T cell-deficient syngeneic mice is driven by low-affinity self-MHC/peptide ligands and the cytokine IL-7. In addition to homeostatic proliferation, a subset of naive T cells undergoes massive proliferation in chronically immunodeficient hosts, but not in irradiated normal hosts. Such rapid T cell proliferation occurs largely independent ...

Journal: :European Journal of Immunology 2021

Tumor Necrosis Factor Receptor 2 (TNFR2) expression is increasingly being linked to tolerogenic immune reactions and cells with suppressor function including a subset of T-regulatory cells. B-regulatory play an important role in control T-cell responses inflammation. Recently, we described TNFR2 as marker for IL-10-producing B cells, hallmark this cell subset. Here, demonstrate that proliferati...

Journal: :Journal of Immunology 2023

Abstract Nutrient metabolism governs the effector functions like activation, expansion, and subset differentiation of CD4 +T-cells, orchestrators adaptive immunity. The levels reactive oxygen species (ROS), metabolic byproducts cellular are regulated by antioxidation pathway, which is composed Keap1 Nrf2 proteins. We observed that, expression temporally post-activation in +T-cells (high on day ...

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