نتایج جستجو برای: sy5y cells

تعداد نتایج: 1383827  

2014
P. K. Leong P. Y. Lam N. Chen K. M. Ko

In the present study, we aim to define the cytoprotective mechanism of ()schisandrin B [()Sch B] in comparison with other phytochemicals in SH-SY5Y cells. The effects of ()Sch B and curcumin (Cur), resveratrol (Rev) and epigallocatechin gallate (EGCG) on -amyloid (A)-induced apoptosis were investigated in SH-SY5Y cells. Cellular reduced glutathione (GSH) levels and peroxide-induced GSH dep...

2010
Francesca Cecere Annarita Iuliano Francesco Albano Claudia Zappelli Immacolata Castellano Pasquale Grimaldi Mariorosario Masullo Emmanuele De Vendittis Maria Rosaria Ruocco

Diclofenac, a nonsteroidal anti-inflammatory drug, induces apoptosis on the neuroblastoma cell line SH-SY5Y through a mitochondrial dysfunction, affecting some antioxidant mechanisms. Indeed, the time- and dose-dependent increase of apoptosis is associated to an early enhancement of the reactive oxygen species (ROS). Mitochondrial superoxide dismutase (SOD2) plays a crucial role in the defence ...

2014
Xavier Bisteau Philipp Kaldis

Contrary to malignant brain tumors arising in adults such as glioma, neuroblastoma develops in young children and is the most common aggressive cancer diagnosed in the first year after birth. Neuroblastoma is an embryonic tumor originating from the migratory neural crest and arises in tissues of the sympathetic nervous system (Maris, N. Engl. Because of its origin, neuroblastoma exhibits a larg...

2017
Sandeep Vasant More Dong-Kug Choi

Oxidative stress and apoptosis are the major mechanisms that induce dopaminergic cell death. Our study investigates the protective effects of atractylenolide-I (ATR-I) on 1-methyl-4-phenylpyridinium (MPP⁺)-induced cytotoxicity in human dopaminergic SH-SY5Y cells, as well as its underlying mechanism. Our experimental data indicates that ATR-I significantly inhibits the loss of cell viability ind...

2015
Yuanli Dong Mei Li Shaojie Wang Yuwei Dong Hongxia Zhao Zhong Dai

BACKGROUND Hypocretin (HCRT) signaling plays an important role in the pathogenesis of narcolepsy and can be significantly influenced by Chinese herbal therapy. Our previous study showed that xingshentongqiao decoction (XSTQ) is clinically effective for the treatment of narcolepsy. To determine whether XSTQ improves narcolepsy by modulating HCRT signaling, we investigated its effects on SH-SY5Y ...

2014
Guobin Li Haiying Yang Dezhang Zhu Hui Huang Guoyuan Liu Peng Lun

Chaperone-mediated autophagy (CMA) is involved in wild-type α-synuclein degradation in Parkinson's disease (PD), and LAMP2A and Hsc 70 have recently been indicated to be deregulated by microRNAs. To recognize the regularory role of miR-320a in CMA and the possible role in α-synuclein degradation, in the present study, we examined the targeting and regulating role of miR-320 in Hsc 70 expression...

2017
In-Su Kim Sushruta Koppula Shin-Young Park Dong-Kug Choi

We employed transcriptome analysis of epidermal growth factor receptor related gene expression changes in cellular and animal models of Parkinson's disease (PD). We used a well-known Parkinsonian toxin 1-methyl-4-phenylpyridine (MPP⁺) to induce neuronal apoptosis in the human neuroblastoma SH-SY5Y cell line. The MPP⁺-treatment of SH-SY5Y cells was capable of inducing neuro-apoptosis, but it rem...

Journal: :Neuroscience 2011
R S Anderton B P Meloni F L Mastaglia W K Greene S Boulos

Spinal muscular atrophy (SMA), a neurodegenerative disorder primarily affecting motor neurons, is the most common genetic cause of infant death. This incurable disease is caused by the absence of a functional SMN1 gene and a reduction in full length survival of motor neuron (SMN) protein. In this study, a neuroprotective function of SMN was investigated in differentiated human SH-SY5Y cells usi...

2015
Hee Ra Park Heeeun Lee Hwayong Park Jong Wook Jeon Won-Kyung Cho Jin Yeul Ma

BACKGROUND Oxidative stress is involved in neuronal cell death and mitochondrial dysfunction in neurodegenerative diseases. Liriope platyphylla (LP) has been suggested to have anti-inflammation, anti-bacterial, and anti-cancer effects. However, whether LP exerts neuroprotective effects on neuronal cells is unknown. METHODS The present study was performed to investigate the neuroprotective eff...

Journal: :Molecules 2016
Liang Cai Li-Fang Wang Jun-Ping Pan Xiang-Nan Mi Zheng Zhang Hai-Ju Geng Jia-Hui Wang Song-Hui Hu Wei Zhang Qin Gao Wu-Tian Wu Huan-Min Luo

This study investigated the neuroprotective effects of methyl 3,4-dihydroxybenzoate (MDHB) against t-butyl hydroperoxide (TBHP) induced oxidative damage in SH-SY5Y (human neuroblastoma cells) and the underlying mechanisms. SH-SY5Y were cultured in DMEM + 10% FBS for 24 h and pretreated with different concentrations of MDHB or N-acetyl-l-cysteine (NAC) for 4 h prior to the addition of 40 μM TBHP...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید