OBJECTIVE To assess the effect of armodafinil, 150 mg, on the physiologic propensity for sleep and cognitive performance during usual night shift hours in patients with excessive sleepiness associated with chronic (> or =3 months) shift work disorder (SWD) of moderate or greater severity. PATIENTS AND METHODS This 12-week, randomized controlled study was conducted at 42 sleep research facilit...

The mechanisms underlying electrophysiologically observed two-way transitions between absence and tonic-clonic epileptic seizures in cerebral cortex remain unknown. The interplay within thalamocortical network is believed to give rise to these epileptic multiple modes of activity and transitions between them. In particular, it is thought that in some areas of cortex there exists feedforward inh...

Abstract Introduction Evidence suggests that individuals with generalized anxiety disorder exhibit decreases in slow-wave sleep (SWS). Because SWS has been shown to be modifiable, it is imperative better understand the relationship between symptoms of and amount inform treatment development. This study aimed explore SWS, investigate impact disruption on state anxiety. Methods Twenty-seven parti...

PURPOSE The AY-9944 (AY)-treated rat is a reproducible and clinically relevant animal model of atypical absence seizures. AY inhibits cholesterol synthesis, but the relation between brain sterol levels and the spontaneously recurrent absence seizures has not been determined. METHODS Long-Evans hooded rats were treated every 6 days from postnatal day (P)2 to P20 with AY (7.5 mg/kg, s.c.) or sa...

Electroencephalographic generalized spike and wave discharges (SWD), the hallmark of human absence seizures, are generated in thalamocortical networks. However, the potential alterations in these networks in terms of the efficacy of the reciprocal synaptic activities between the cortex and the thalamus are not known in this pathology. Here, the efficacy of these reciprocal connections is assess...

Understanding the fine-scale genome sequence diversity that exists within natural populations is important for developing models of species migration, temporal stability, and range expansion. For invasive species, agricultural pests, disease vectors, at specific loci in can impact efficacy next-generation genetic biocontrol strategies. Here we describe a pipeline haplotype-resolution variant di...

OBJECTIVE To compare the effectiveness of transcutaneous electrical nerve stimulation (TENS), interferential currents (IFCs), and shortwave diathermy (SWD) against each other and sham intervention with exercise training and education as a multimodal package. DESIGN A double-blind, randomized, controlled, multicenter trial. SETTING Departments of physical medicine and rehabilitation in 4 cen...

Abstract Populist radical right (PRR) parties are increasingly included in coalition governments across Western Europe. How does such inclusion affect satisfaction with democracy (SWD) these societies? While some citizens will feel has grown more responsive, others abhor the of controversial parties. Using data from European Social Survey (2002–2018) and panel Netherlands, we investigate how na...

• Some aspects of standardized testing make the administration of these tests infeasible or unfair to certain students, particularly students with disabilities (SWD). To address this problem, many tests are altered, or the test administration conditions are adjusted, to “accommodate” the special needs of these students. This practice is designed to level the playing field so that the format of ...