Chronic liver injury, as observed in non-alcoholic steatohepatitis (NASH), progressive fibrosis, and cirrhosis, remains poorly treatable. Steatohepatitis causes hepatocyte loss part by a direct lipotoxic insult, which is amplified derangements the non-parenchymal cellular (NPC) interactive network wherein hepatocytes reside, including, hepatic stellate cells, sinusoidal endothelial cells macrop...

Obesity and its associated comorbidities are among the most prevalent and challenging conditions confronting the medical profession in the 21st century. A major metabolic consequence of obesity is insulin resistance, which is strongly associated with the deposition of triglycerides in the liver. Hepatic steatosis can either be a benign, noninflammatory condition that appears to have no adverse ...

â  â  background a substantial proportion of the mortality in patients with type 2 diabetes mellitus (t2dm) is related to non-alcoholic fatty liver disease (nafld) and its complications. insulin resistance is a major etiologic factor for the development of fatty liver. we aimed to study the prevalence of nafld among t2dm patients and its relation to insulin resistance. methods patients with t2d...

The аim of research – to establish the probable eff ect Bicyclol on clinicalmanifestations nonalcoholic steatohepatitis, markers hepatocyte cytolysis,cholestasis, mesenchymal infl ammation in patients with steatohepatitisnonalcoholic and diabetes mellitus type 2, degree hepatocytesteatosis stage liver fi brosis.Methods. Studies were conducted treatment dynamics 60 NASHwith 2 moderate severity. ...

This article reviews diagnostic criteria for nonalcoholic steatohepatitis (NASH), current grading and staging methodology, and diagnostic challenges and pitfalls in routine practice. Current practice guidelines and prognostic and treatment considerations are discussed. The clinical diagnosis of nonalcoholic fatty liver disease may represent stable disease without progressive liver damage, in th...

The increasing prevalence of obesity and the metabolic syndrome worldwide is well recognized, the tight association of non-alcoholic fatty liver disease (NAFLD) with these conditions increasingly so. NAFLD can progress to the more severe form of the disorder non-alcoholic steatohepatitis (NASH), which is characterized by worsening liver pathology. The prevalence of iron disorders, in particular...

This comment discusses the study by Videla and colleagues in this issue of Clinical Science in which they have analysed surgical liver biopsies from obese patients with non-alcoholic fatty liver disease and demonstrate that fatty liver is associated with a state of oxidative stress and a decreased antioxidant activity. As the disease progresses to steatohepatitis, the defect in antioxidant syst...

BACKGROUND Obesity and diabetes are frequently associated with nonalcoholic steatohepatitis (NASH), but studies have been hampered by the absence of a suitable experimental model. OBJECTIVE Our objective was to create a rat model of NASH. DESIGN Sprague-Dawley rats were fed a high-fat, liquid diet (71% of energy from fat, 11% from carbohydrates, 18% from protein) or the standard Lieber-DeCa...

INTRODUCTION Nonalcoholic steatohepatitis (NASH), a subset of nonalcoholic fatty liver disease (NAFLD), is becoming an increasing health concern, with current data showing the prevalence in the United States to range between 5.7%–16.5% (1,2). Patients with NASH lack a history of significant alcohol consumption, but liver biopsy findings are almost identical to biopsy findings in patients with a...