Pulmonary inhalation chemotherapeutic drug delivery offers many advantages for lung cancer patients in comparison to conventional systemic chemotherapy. Inhalable particles are advantageous in their ability to deliver drug deep in the lung by utilizing optimally sized particles and higher local drug dose delivery. In this work, spray-dried and co-spray dried inhalable lung surfactant-mimic PEGy...

In the sphere of drug delivery, denatured whey protein (DWP) has in recent times gained press. However, to date, no scalable and affordable dosage form has been developed. The objective of our study was to evaluate the potential use of spray-dried DWP as a ready to use excipient for oral drug delivery. Therefore, solid state, FTIR spectra and wettability were studied. Dissolution, mucoadhesion ...

In this study, applications of ultrasound in food drying processes have been reviewed. High frequency ultrasonic treatment can be used in food drying processes as a pretreatment or for the improvement of the main process and the traditional driers. Ultrasonic waves at low frequency can also be used as a diagnostic method for measuring properties of the final dried products and controlling the d...

INTRODUCTION Nanocomposite microparticles are intelligent carriers utilised for pulmonary drug delivery. These carriers are composed of drug-encapsulated nanoparticles dispersed in microstructures of polysaccharides. Upon administration, the inhaled microparticles can penetrate and be deposited deeply in the lung due to their adjusted aerodynamic particle size. Subsequently, the nanoparticles a...

A powder vaccine intended for aerosol vaccination of poultry was formulated by spray drying a live attenuated Newcastle disease virus with potential stabilizers (mannitol, trehalose, polyvinylpyrrollidone (PVP), bovine serum albumin (BSA)). Thermodynamic properties, water sorption, particle size distribution, nebulization properties, density and morphology of the powders were evaluated and the ...

OBJECTIVE Feeding bovine colostrum (BC) improves gut maturation and function and protects against necrotizing enterocolitis, relative to formula in newborn preterm pigs. Before BC can be used for preterm infants, it is important to test if the milk processing, required to reduce bacterial load and increase shelf life, may affect bioactivity and efficacy of a BC product. METHODS We investigate...

Microspheres containing yttrium (Y) and/or phosphorus (P) around 25 μm are useful for radioembolization therapy because they are activated to β-emitter by neutron bombardment and infused in blood vessels in the neighborhood of tumors to irradiate β-rays to the tumors. In this study, we attempt to prepare Y and P-containing microspheres by spray drying method. Starting solution containing yttriu...

In previous studies nano sized hydroxyapatite (HA) particles were prepared by solgel or precipitation methods, in which the products were washed by aqueous or non-aqueous liquids to remove impurities or undesired components. The washing is know to modify the surfaces of the cystalline particles. This study evaluated properties of nano HA materials prepared by a spray drying method in which the ...

A general aim of the research was to develop a technology of manufacturing microspheres with losartan potassium as an active substance, and Eudragit L30D55 as a matrix with the use of spray drying technique. During the first step of the study, optimal values of parameters in spray drying process were established (i.e., operating temperature, peristaltic pump performance, aspiration value). Thos...

The Aim of this study was preparation of dry powder formulation of rifampicin loaded polymeric microparticles as dry powder formulation for inhalation in effective tuberculosis treatment.The microparticles containing rifampicin (RIF) were prepared by spray drying method using different biocompatible polymers like chitosan and hydroxyl propyl methyl cellulose (HPMC) The microparticles and microp...