The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for alpha(1)-, alpha(2)- and beta(1)-adrenocep...

Bulgarian medicinal plants, which have been studied during the last years, are reviewed. The review includes the following families: Amaryllidaceae, Asteraceae, Berberidaceae, Boraginaceae, Fabaceae, Geraniaceae, Lamiaceae, Oleaceae, Onagraceae, Scrophulariaceae, Solanaceae, Ranunculaceae, Rosaceae, Rutaceae, Valerianaceae, Zygophyllaceae. Main pharmacological properties are antiviral, antimicr...

The aqueous-ethanol extract of the Hypericum perforatum (Hp-Ext.) was studied for its possible effect on Naloxone (NLX)-precipitated Opium withdrawal physical signs in rats. Purified Opium was used to induce dependence in rats using 8 days treatment schedule. The animals received Opium extract orally twice daily at 09:00 hrs and 19:00 hrs starting with initial dose of 80 mg/kg (equivalent to 8 ...

The aqueous-ethanol extract of the Hypericum perforatum (Hp-Ext.) was studied for its possible effect on Naloxone (NLX)-precipitated Opium withdrawal physical signs in rats. Purified Opium was used to induce dependence in rats using 8 days treatment schedule. The animals received Opium extract orally twice daily at 09:00 hrs and 19:00 hrs starting with initial dose of 80 mg/kg (equivalent to 8 ...

PURPOSE To compare the efficacy of different treatment strategies for distal ureteral stones smaller than 10 mm. MATERIAL AND METHODS A total 127 patient were included in the study. Based on the treatment modality , patients were divided into three groups.Patients in group 1 only received conventional treatment including daily hydration of 2500 mL, ciprofloxacin, diclofenac sodium and a spasm...

Introduction: Dill (Anethum graveolens), a herb from from Umbelliferae, is used traditionally to treat convulsion and increasing milk production. Its antimicrobial, antihyperlipidaemic, anti-hypercholesteroaemic effects and gastric acid secretion reducing effect have been reported. The spasmolytic effect of dill fruit on rat uterus has also been shown recently. The aim of present study was to i...