zataria multiflora boiss. is used in iranian traditional medicine to treat gastrointestinal disorders and menrrhalgia. the inhibitory effect of this herb on rat ileum contractions is also reported. the aim of this study was to investigate the effect of zataria multiflora boiss. hydroalcoholic leaf extract (zhle) on isolated rat uterus in presence of some known uterus stimulants. pieces of virgi...

The present study aimed to investigate the correlation between structure and spasmolytic activity of racemate and enantiomers of linalyl and citronellyl acetates, chemical constituents of several bioactive essential oils, such as Thymus leptophyllus essential oil, which contains linalyl acetate as major constituent. The monoterpene esters showed significant spasmolytic activity in guinea-pig is...

Rotundifolone, a monoterpene isolated from the essential oil of the leaves of Mentha x villosa, is a constituent of several essential oils and known to have spasmolytic activity. The present study aimed to investigate the correlation between structure and spasmolytic activity of rotundifolone and its analogues in ileum isolated from guinea-pig. Five of the seven tested analogues were found to h...

are oestrogen-dependent (Katzenellenbogen, 1980; McGuire, 1980). The MCF-7 cell line (Lippman & Bolan, 1975), a human breast cancer cell line, has been especially useful for understanding the mechanism of action of oestrogen. The pS2 protein (Mr 6500) is an abundant oestrogen-induced protein secreted by MCF-7 cells and found in breast tumour tissue (Masiokowski et al., 1982; Jakowlew et al., 19...

The aqueous-ethanolic extract of the Hibiscus rosasinensis aerial parts (Hr.Cr) was studied for the possible presence of spasmogenic and spasmolytic constituents to rationalize some of its traditional uses in gastrointestinal disorders. Segments of isolated rabbit jejunum and guinea-pig ileum, 2-3 cm long were mounted seprately in Tyrode’s solution and aerated with 95% oxygen in carbon dioxide....

BACKGROUND AND OBJECTIVES The current investigation was carried out to explore the pharmacological basis of the crude extract of Conyza bonariensis (Cb.Cr) for its use in constipation and diarrhea. MATERIALS AND METHODS The plant extract of Conyza bonariensis (C. bonariensis) was prepared, isolated guinea-pig ileum and rabbit jejunum preparations were used to evaluate its gut modulator effect...

INTRODUCTION Jasonia glutinosa is an endemic plant species of the Iberian Peninsula and Southern France traditionally used in infusions as a spasmolytic; this plant is also known as "té de roca" (rock tea) but there is no scientific evidence about the effects of this plant. AIM To evaluate the spasmolytic effect of rock tea. METHODS We have studied the in vitro effect of a rock tea extract ...

Background: Alchemilla abyssinica is a plant widely used in traditional medicine. Its wide use among the community plus already established scientific evidences for medicinal values of other Alchemilla species provided good ground for this investigation. Methods: In this research, CHCl3/EtoAc 1:1 extract of dried aerial parts of Alchemilla abyssinica, methanolic extract of the CHCl3/ EtoAc resi...

Antibacterial activity on ATCC strains of Escherichia coli, Salmonella enterica, Salmonella enteritidis, and Salmonella choleraesuis and spasmolytic effect on contraction on rat ileum trips were determinate. Eight organic extracts (hexanic and methanolic) of albedo (mesocarp) and flavedo (pericarp) of two varieties (Valencian and National) of Citrus sinensis (L.) Osbeck of Yucatán, México, were...

In previous general screening experiments was found a potent spasmolytic effect in guinea-pig ileum promoted by a furanoflavan-type flavonoid 3,4,5,8-tetramethoxy-(6,7,2”,3”)-furanoflavan named diplotropin, obtained from the stem-barks of Lonchocarpus araripensis Benth., which effect is due, in part, to the inhibition of Ca influx through voltage-dependent Ca channels. This study demonstrates f...