PURPOSE Infantile spasm is an age-dependent epileptic syndrome seen in infancy or early childhood. Although studies have investigated the epilepsy-cytokine relationship, there has been insufficient research into the relation between cytokines and infantile spasm. The purpose of this study was to examine the role of cytokines in the pathogenesis of infantile spasm by investigating cytokine level...

STUDY OBJECTIVES This study was performed to compare the results of accelerated exercise following mild hyperventilation and a standard acetylcholine (ACh) test for the induction of coronary artery spasm in patients with drug-induced coronary artery spasm. METHODS AND RESULTS The subjects were 74 patients with angiographically confirmed coronary artery spasm who were examined using accelerate...

The therapeutic approach to poliomyelitis thus far must concern itself with the relief of so-called muscle spasm and the prevention of deformities. Since the advent of the modern concept of muscle spasm there has been a general trend toward the use of hot pack therapy, because it is thought that spasm is an inherent pathological mechanism within the muscle itself (Pohl, 1942, 1947) essentially ...

PURPOSE We experienced 3 cases of serious perioperative coronary artery spasm in off-pump coronary artery bypass grafting (OPCAB). In consideration of the causes, we directed our attention to hypomagnesemia, one of the triggers of coronary artery spasm. This study was performed to confirm the tendency to hypomagnesemia in OPCAB. METHODS First, we report 3 patients having severe coronary arter...

BACKGROUND AND OBJECTIVES The gender differences among Korean patients with coronary spasm have not been defined. We thus determined the gender differences among Korean patients with coronary spasm. SUBJECTS AND METHODS Patients with chest pain and/or syncope who were admitted to Kyungpook National University Hospital between January 2001 and August 2008 were included. Provocation of coronary...

Control of Cerebral Vasospasm by Parenteral Phenoxybenzamine • Cerebral vasospasm has been studied in the basilar artery of the cat. The ability of alpha adrenergic blocking agents to prevent and alleviate spasm produced by the application of blood to the basilar artery has been investigated. Parenteral phenoxybenzamine is effective in preventing spasm under these experimental conditions when g...

Study of Cannon et aI. Cannon and colleagues (2) demonstrated inappropriate arteriolar constriction in patients with atyp ical chest pain and msignificant coronary artery disease. These cases . which may represent a distin ct syndrome. offer a number of lines of evidence. First. Cannon et al. demon strated for the first time that . 'v asoconstrictor stimuli act ing at the arter iolar level can ...

Hemimasticatory spasm is a rare neurologic disorder characterized by unilateral, paroxysmal involuntary contraction of the masticatory muscles. It can be confused with other unilateral facial spasms. In this report, we present two patients with hemimasticatory spasm who were initially misdiagnosed with other disorders. The first patient was a 54-year-old man with a 9-year history of right facia...

Objective: To investigate the association between primary hemifacial spasm and arterial hypertension. Subjects: 114 patients with primary hemifacial spasm and 228 neurological controls, matched for age, sex, and referral centre, were recruited during an 18 month period from consecutive outpatients attending two neurological institutions. Design: The association between exposure variables and ca...

BACKGROUND/OBJECTIVE Guaifenesin, an over-the-counter (OTC) expectorant, has exhibited muscle relaxant effects preclinically and clinically. This proof-of-principle study explored whether OTC doses of guaifenesin can provide relief from acute upper back, neck, or shoulder muscle spasm and pain. METHODS This multicenter, placebo-controlled, repeat-dose, parallel study randomly assigned adults ...