نتایج جستجو برای: signalling pathway
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The spindle assembly checkpoint is a conserved mitotic signalling pathway that ensures the equal segregation of chromosomes to daughter cells. Despite intensive work in many model organisms, key features of this safety mechanism remain unexplained. In the present review, I briefly summarize advances made in the last few years, and then focus on unexplored corners of this signalling pathway.
Ventral midline cells in the neural tube form floorplate throughout most of the central nervous system (CNS) but in the anterior forebrain, they differentiate with hypothalamic identity. The signalling pathways responsible for subdivision of midline neural tissue into hypothalamic and floorplate domains are uncertain, and in this study, we have explored the role of the Wnt/Axin/beta-catenin pat...
Endothelial dysfunction is characterised by aberrant redox signalling and an inflammatory phenotype. Shear stress antagonises endothelial dysfunction by increasing nitric oxide formation, activating anti-inflammatory pathways and suppressing inflammatory pathways. The TAK1 (MAP3K7) is a key mediator of inflammation and non-canonical TGF-β signalling. While the individual roles of TAK1, ERK5 (MA...
The Notch signalling pathway is conserved among higher metazoans and is used repeatedly throughout development to specify distinct cell fates among populations of equipotent cells. Mounting evidence suggests that Notch signalling may also be crucial in neuronal function in postmitotic, differentiated neurons. Here, we demonstrate a novel role for the canonical Notch signalling pathway in postmi...
Communication among cells was paramount to the evolutionary increase in cell type diversity and, ultimately, the origin of large body size. Across the diversity of Metazoa, there are only few conserved cell signalling pathways known to orchestrate the complex cell and tissue interactions regulating development; thus, modification to these few pathways has been responsible for generating diversi...
Inhibitors of apoptosis signaling in cellular apoptosis. Apoptosis and Cancer related products in the Abcam Biochemicals range.cancer signaling is that cancer cells may become addicted to specific. Ical signaling pathways involved in cancer initiation and progression heavily rely on.The Pathways in Human Cancer poster summarizes some of the key Ras Common pmtein name signaling pathways implicat...
The non-canonical Wnt/planar cell polarity (Wnt/PCP) pathway plays a crucial role in embryonic development. Recent work has linked defects of this pathway to breast cancer aggressiveness and proposed Wnt/PCP signalling as a therapeutic target. Here we show that the archetypal Wnt/PCP protein VANGL2 is overexpressed in basal breast cancers, associated with poor prognosis and implicated in tumour...
118 WNT signalling and the initiation of CRC Around 70% of sporadic colorectal tumours show biallelic inactivation of the APC gene (Adenomatous polyposis Coli). A high percentage of remaining tumours show activating mutations in beta-catenin or axin. These molecules are components of the Wnt signalling pathway. Activating mutations of the Wntsignalling pathway are the only known genetic alterat...
The gaseous plant hormone ethylene plays critical roles in plant responses to environmental and endogenous signals that modulate growth and development. Over the past 25 years, great progress has been made in elucidating the ethylene signalling pathway. Genetic studies in Arabidopsis thaliana have identified key components of the pathway, and subcellular localization studies have shown that mos...
The Hedgehog (Hh) signalling pathway has a crucial role in several developmental processes and is aberrantly activated in a variety of cancers. In Drosophila, many of the canonical Hh pathway components are phosphorylated, yet the precise role of these phosphorylation events in the regulation of Hh signal transduction is unclear. Furthermore, the Hh pathway receives input from several kinases t...
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