Background: Activation of the unfolded protein response (UPR) is closely related to pathogenesis many metabolic disorders. Accumulating evidence also shows that UPR and signaling pathways are interdependent. The AMP-activated kinase (AMPK) signal pathway controls energy balance eukaryotes. aim this study was therefore investigate possible interaction between AMPK in muscle cells exposed saturat...

RATIONALE Although a cardioprotective function of target of rapamycin (TOR) signaling inhibition has been suggested by pharmacological studies using rapamycin, genetic evidences are still lacking. We explored adult zebrafish as a novel vertebrate model for dissecting signaling pathways in cardiomyopathy. OBJECTIVE We generated the second adult zebrafish cardiomyopathy model induced by doxorub...

background: osteosarcoma is a malignant tumor with high mortality but effective therapy has not yet been developed. berberine, an isoquinoline alkaloid component in several chinese herbs including huanglian, has been shown to induce growth inhibition and the apoptosis of certain cancer cells. the aim of this study was to determine the role of berberine on human osteosarcoma cell lines u2os and ...

The modulation of the activity tyrosine kinases (TK) is an appealing topic current research. This work presents new pseudopeptidic cages that protect substrates from action TK enzyme, precluding corresponding Tyr phosphorylation, with a very good correlation between caging and kinase inhibition. results illustrate how signaling can be efficiently selectively modulated supramolecular complexes. ...

Lateral inhibition mediated by Delta/Notch (Dl/N) signaling is used throughout development to limit the number of initially equivalent cells that adopt a particular fate. Although adjacent cells express both Dl ligand and N receptor, signaling between them ultimately occurs in only one direction. Classically, this has been explained entirely by feedback: activated N can downregulate Dl, amplify...

Abstract Thrombospondin-1 (TSP-1) is released by platelets upon activation and can increase platelet activation, but its role in hemostasis vivo unclear. We show that TSP-1 a critical mediator of promotes modulating inhibitory cyclic adenosine monophosphate (cAMP) signaling. Genetic deletion did not affect vitro, models thrombosis showed TSP-1–deficient mice had prolonged bleeding, defective th...

Tumor necrosis factor receptor 1 (TNFR1) activates NF-?B–dependent pro-inflammatory gene expression, but also induces cell death by triggering apoptosis and necroptosis. Inhibition of inhibitor NF-?B kinase (IKK)/NF-?B signaling in keratinocytes paradoxically unleashed spontaneous TNFR1-mediated skin inflammation mice, the underlying mechanisms remain poorly understood. Here, we show that TNFR1...