The case is reported of a 35 year old heroin addict presenting with acute confusion which was later found to be due to meningococcal meningitis. Other than his altered mental state, the only abnormal finding on examination was a mild pyrexia.

THE METHADONE Maintenance Research Program began three years ago with pharmacological studies conducted on the metabolic ward of the Rockefeller University Hospital. Only six addict patients were treated during the first year, but the results of this work were sufficiently impressive to justify the trial of maintenance treatment of heroin addicts admitted to open medical wards of general hospit...

Metastatic candida endophthalmitis presented as a unilateral panuveitis in an apparently healthy drug addict. Diagnosis was confirmed by vitrectomy. The eye made an excellent response to treatment with the new antifungal drug, ketoconazole, and 5-fluorocytosine. Problems raised in the diagnosis and management of this infection are discussed.

1. Laertes is about to stab Hamlet. Claudius, watching from the wings, desperately wants Laertes to stab Hamlet and has implanted a device in Laertes’ brain that, if activated, will force him to stab Hamlet. Claudius intends to activate the device if it appears that Laertes will change his mind at the last moment. Laertes, however, stabs Hamlet of his own accord and Claudius’s device is never a...