A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.

Three new photochromic coumarins were synthesized. Fluorescence of the open form of 7-hydroxy-3,4-bisthiazolyl-coumarin increased to 1400% by changing the pH only slightly from 6.05 to 7.58. This was subsequently quenched to 1.5% of the maximum intensity at the UV photostationary state in water-methanol media.

re-investigation of the methylene chloride extract of the roots of ferula sinaica gave ferusinol, a new sesquiterpene coumarin with a rare carbon skeleton, and samarcandin diastereomer. the structures elucidation were determined by ms, 1h- 13c-1d and 2d nmr spectral data.

leishmaniasis has a wide spectrum of signs and symptoms due to infection to numbers of leishmania species and makes enormous mortality and morbidity. there are clues of antileishmanial effects of prenylated coumarins. apiaceae family is one of the most important sources of coumarins. air-dried aerial parts of ferulago angulata and fruits of prangos asperula were extracted with n -hexane, using ...

BACKGROUND Treatment with vitamin K antagonists (coumarins) is associated with an increased risk of bleeding. Because use of selective serotonin reuptake inhibitors (SSRIs) is also associated with an increased risk of bleeding, we assessed the odds ratio (OR) of abnormal bleeding associated with SSRI use in users of the coumarins acenocoumarol or phenprocoumon and compared this with the OR of b...

Endothelial cells (ECs) are key players in inflammation and immune responses involved in numerous pathologies. Although attempts were experimentally undertaken to prevent and control EC activation, drug leads and probes still remain necessary. Natural products (NPs) from Clusiaceous and Calophyllaceous plants were previously reported as potential candidates to prevent endothelial dysfunction. T...

Coumarin and its derivatives represent one of the most active curriculums compound possessing a broad spectrum biological activity along with other applications such as insecticide fragrance. There are various methodologies developed for synthesis coumarins. Classical routes to coumarins include Pechmann condensation, Knoevenagel Perkin reaction, Wittig condensation reactions. Researchers have ...