the regulation of dopamine and serotonin synthesis in rat brain striatal synaptosomes has been studied using hplc methods. noradrenaline was shown to markedly inhibit both the synthesis of dopamine and serotonin. the response of the synaptosomes to the concentrations of noradrenaline appeared to be biphasic, a very effective inhibition occurring at low concentrations (1-5 µm) and a relatively i...

Background Major depressive disorder is a common condition that often includes cognitive dysfunction. A systematic literature review of studies and a network meta-analysis were carried out to assess the relative effect of antidepressants on cognitive dysfunction in major depressive disorder. Methods MEDLINE, Embase, Cochrane, CDSR, and PsychINFO databases; clinical trial registries; and relev...

This article proposes a number of recommendations for the treatment of generalized social phobia, based on a systematic literature review and meta-analysis. An optimal treatment regimen would include a combination of medication and psychotherapy, along with an assertive clinical management program. For medications, selective serotonin reuptake inhibitors and dual serotonin-norepinephrine reupta...