SECTION 1 A 33-year-old man with an unremarkable medical history presented to an outside hospital emergency department (ED) in January 2011 with altered mental status and a seizure. Four days prior to his admission, his children experienced fevers and body aches that self-resolved. The patient developed similar symptoms 3 days later that he treated with acetaminophen and ibuprofen. On the morni...

BACKGROUND AND THE PURPOSE OF THE STUDY Lamotrigine is a broad spectrum anticonvulsant drug widely used as mono- or adjunct- therapy in adults and children. The aim of this study was to develop controlled release liquid formulation of lamotrigine to improve bioavailability and compliance of pediatric and geriatric epileptic patients. METHODS Multiple (w/o/w) emulsion was prepared using one st...

Understanding the role of SCN8A in epilepsy and behavior is critical in light of recently identified human SCN8A epilepsy mutations. We have previously demonstrated that Scn8a(med) and Scn8a(med-jo) mice carrying mutations in the Scn8a gene display increased resistance to flurothyl and kainic acid-induced seizures; however, they also exhibit spontaneous absence seizures. To further investigate ...

introduction: this study was aimed to asses the rate of recurrence after the first unprovoked seizure in children. methods and materials: in a prospective study, we recruited 145 children who presented with primary unprovoked seizure and were followed for at least 12 months after the first seizure. results: seventy five children (51.7%) experienced subsequent seizures. the cumulative risk of se...

objective febrile seizure is the most common problem in pediatric neurology that occurs in 3- 4 % of children. the purpose of this study was to determine febrile seizure recurrence frequency and to evaluate its risk factors. materials & methods in a descriptive prospective study, 139 children (6 months to 6 years) with first febrile seizure were admitted to yazd shaheed sadoughi hospital betwee...

The series of N-[(4-arylpiperazin-1-yl)-alkyl]-3-phenyl- and 3-(3-methylphenyl)-pyrrolidine-2,5-diones [VIII-XXV] were synthesized and evaluated for anticonvulsant and neurotoxic properties. Initial anticonvulsant screening was performed in mice, using intraperitoneal (ip) maximal electroshock-induced seizures (MES) and subcutaneous pentylenetetrazole-induced (scPTZ) seizure threshold tests. Th...

Mitochondrial targeted radiation damage protectors (delivered prior to irradiation) and mitigators (delivered after irradiation, but before the appearance of symptoms associated with radiation syndrome) have been a recent focus in drug discovery for (1) normal tissue radiation protection during fractionated radiotherapy, and (2) radiation terrorism counter measures. Several categories of such m...

The anticonvulsant effects of 3,4-Dimethoxy toluene (DMT), the major constituent of the date palm (Phoenix dactylifera L.) spathe, were investigated using pentylenetetrazole (PTZ), picrotoxin (Pic), nicotine (Nic) and maximal electroshock (MES)-induced seizure models. In PTZ (85 mg/kg)-induced seizures, the intraperitoneally injection of DMT at a dose of 100 mg/kg significantly delayed the onse...

Expression of the rat (RH-I/SkM2) and human (hH1/SCN5A) tetrodotoxin-resistant (TTX-R), voltage-sensitive sodium channels is thought to be specific to cardiac tissue. We detected RH-I/SkM2 mRNA in newborn rat brain using both RNase protection assay analysis and in situ hybridization and in adult rat brain using RNase protection assay analysis. This expression was observed primarily in developin...