In recent years, signiÞ cant interest has been shown in the development of novel bioadhesive dosage forms for mucosal delivery of drugs that attempt to overcome these limitations1. A bioadhesive dosage form necessitates the use of mucoadhesive polymers to adhere to mucosa and withstand salivation, tongue movement and swallowing for signiÞ cant period of time2. High molecular weight polymers are...

ABSTRACT: Macrocyclic lactones are widely used as endectocides in farm animals. Intoxications occur situations of overdose and/or malnutrition, young animals, and genetically sensitive breeds. We describe the intoxication by doramectin malnourished 15-month-old cattle that received 1.6 times recommended dose. The animals presented salivation, ataxia, motor incoordination, reluctance to move, st...