abstract objective removing plasma from the platelet concentrate (pc) medium could be an effective way to increase the safety of this product. the goal of this study was to compare pc stored in plasma or in an additive solution (composol) with in vitro testing. materials and methods fifty-four single donor pcs were prepared from iranian blood transfusion organization (ibto). each pc unit was di...

Intense swimming causes circulatory lactate accumulation in rainbow trout because lactate disposal (Rd) is not stimulated as strongly as lactate appearance (Ra). This mismatch suggests that maximal Rd is limited by tissue capacity to metabolize lactate. This study uses exogenous lactate to investigate what constrains maximal Rd and minimal Ra. Our goals were to determine how exogenous lactate a...

A lactate clamp method has been developed to quantify the whole body lactate utilization in conscious, unstressed rats. Dichloroacetate (DCA), a known lactate utilization enhancer, was used to validate the method. Fasting blood lactate concentrations before the clamps were identical for DCA-treated (1 mmol/kg) and control groups (1.65 ± 0.37 vs. 1.65 ± 0.19 mM). The animals received a primed co...

objective(s): many cancer cells show significant resistance to drugs that kill drug sensitive cancer cells and non-tumor cells and such resistance might be a consequence of the difference in metabolism. therefore, studying the metabolism of drug resistant cancer cells and comparison with drug sensitive and normal cell lines is the objective of this research. material and methods:metabolism of c...

Our knowledge of concussions has increased and our treatment has changed substantially in recent years based on new research. Some of the major changes include the awareness that "minor head injuries," frequently called "bell-ringers or dings," are in fact concussions; many relatively minor head injuries take longer to heal than previously believed; concussions can occur without loss of conscio...

tarnish and corrosion behavior of three commercial dental amalgams namely am.1, am.2, am.3, have been investigated by utilizing in vitro tests. the corrosion and/or dissolution rate of the three dental amalgams were studied in 0.9 wt% nacl solution, artificial saliva and ringers solution. potentiodynamic polarization technique was employed to study cathodic and anodic polarization behavior, fro...