In recent years, exosomes have attracted increasing scientific interest and are no longer considered just as containers for cell waste, but as important mediators of intercellular communication. Among many biomedical research topics, a possible direct role of exosomes in the regenerative medicine field has been underlined in recent studies, including those regarding the so called "paracrine hyp...

3D cultures have gained attention in the field of regenerative medicine for their usefulness as in vitro model of solid tissues. Bottom-up technology to generate artificial tissues or organs is prospective and an attractive approach that will expand as the field of regenerative medicine becomes more translational. We have characterized c-kit positive cardiac stem cells after long-term cultures ...

Tippi C. MacKenzie*, Anna L. David, Alan W. Flake and Graca Almeida-Porada* 1 Eli and Edythe Broad Institute for Regeneration Medicine, University of California, San Francisco, San Francisco, CA, USA 2 Institute for Women’s Health, University College London, London, UK 3 Children’s Hospital of Philadelphia, Philadelphia, PA, USA 4 Wake Forest Institute for Regenerative Medicine, Wake Forest Uni...

PURPOSE OF REVIEW To briefly show which are the mechanisms and cell types involved in kidney regeneration and describe some of the therapies currently under study in regenerative medicine for kidney transplantation. RECENT FINDINGS The kidney contains cell progenitors that under specific circumstances have the ability to regenerate specific structures. Apart from the knowledge gained in the s...

Biomaterials play a pivotal role in regenerative medicine, which aims to regenerate and replace lost/dysfunctional tissues or organs. Biomaterials (scaffolds) serve as temporary 3D substrates to guide neo tissue formation and organization. It is often beneficial for a scaffolding material to mimic the characteristics of extracellular matrix (ECM) at the nanometer scale and to induce certain nat...

1. Center for Lung Regeneration, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15250; 2. Division of Pulmonary, Allergy and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710; 3. The Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases, Pulmonary Allergy and Critical Care Medicine, University of Pittsburgh,...

Kenichi Kawabata, Nobutake Ozeki, Hideyuki Koga, Yusuke Nakagawa, Mio Udo, Ryusuke Saito, Katsuaki Yanagisawa, Toshiyuki Ohara, Kunikazu Tsuji, Takeshi Muneta, Ichiro Sekiya. Department of Joint Surgery and Sports medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan, 3.Department of Cartilage Regeneration, Graduate School, Tokyo Medical and Dental University, Tokyo, Japa...

Knitting is an ancient and yet, a fresh technique. It has a history of no less than 1,000 years. The development of tissue engineering and regenerative medicine provides a new role for knitting. Several meshes knitted from synthetic or biological materials have been designed and applied, either alone, to strengthen materials for the patching of soft tissues, or in combination with other kinds o...

Since over a decade and ever more often we observe a clash between specific “new” living entities and the governance and regulation of (bio-)medical practices. These are the entities we call “bio-objects.” As will become clearer in the following, these bio-objects are indicators of a fundamental change between different systems of thought and practice: this is in the case of medicine the change...

In the last years biologically stable biomaterials gives their place to biodegradable biomaterials in packaging, agriculture, medicine, and other application areas. For applications in medicine this happens because of the some problems caused by the regeneration ability of the living tissues and toxic effect of stable polymers. By products of biodegradable polymers leaves no residual mass at th...