Radionuclide therapy aims to treat malignant diseases by systemic administration of radiopharmaceuticals, often using carrier molecules such as peptides and antibodies. The radionuclides used emit electrons or alpha particles as a consequence of radioactive decay, thus leading to local energy deposition. Administration to individual patients can be tailored with regards to the risk of toxicity ...

Positron emission tomography (PET) is well established as an important research and clinical molecular imaging modality. Although the size differences between humans and rodents create formidable challenges for the application of PET imaging in small animals, advances in technology over the past several years have enabled the translation of this imaging modality to preclinical applications. In ...

Introduction: Artificial and natural radionuclides exist in the environmental materials, such as water, soil, rocks, and plant as well as in animals and human body tissues. Therefore, human being and environment are at constant radiation exposure. Regarding this, the present study aimed to determine the specific activities of radionuclides and perform the risk assessment wheat and barley sample...

INTRODUCTION The largest contribution for the global population exposure to ionizing radiation arises from natural sources, especially from radionuclides present in terrestrial crust. Certain human activities may eventually increase such exposure to significant levels, from the point of view of radiological protection (1, 2). The presence of natural radionuclides in building materials may lead ...

An IAEA research project was dedicated to the compilation, evaluation and recommendation of cross-section data for accelerator production 11C, 13N, 15O, 18F, 64Cu, 124I positron-emitting radionuclides clinically used PET imaging, two gamma emitters, 81Rb 123I, in SPECT imaging. Cross sections 19 charged-particle induced reactions that can be employed radionuclide were evaluated including uncert...

Oncolytic adenoviruses can be engineered for better tumor selectivity, gene delivery and be armed for imaging and concentrating radionuclides into tumors for synergistic oncolysis. We constructed Ad5/3-hTERT-hNIS where replication is controlled by hTERT-promoter. Ad5/3-hTERT-hNIS expresses hNIS for imaging of transgene expression and for treatment of infected tumors by radioiodine. Ad5/3-hTERT-...

We have recently witnessed the heroic efforts of athletes from around the world striving to achieve the Olympic motto— Faster, Higher, Stronger. This could equally be the catch-cry of radiochemists who seek to make tracers with faster synthesis times, higher yields, and stronger binding affinity to the target of choice. Rapid synthesis is particularly important for short-lived radionuclides suc...

Liquid scintillation spectrometry is widely used for the analysis of alpha and beta emitting radionuclides. Robust calibration of liquid scintillation (LS) spectrometers is fundamental to accurate LS measurement but at the same time is time consuming and costly, particularly if a wide range of radionuclides are analysed by the laboratory. The frequency of the calibration varies in different lab...

The mean annual effective dose from natural radionuclides for users of drilled wells was estimated to be 0.41 mSv, for users of wells dug in the ground 0.05 mSv and for people using water from waterworks 0.02 mSv. The highest effective dose from drinking water was caused by 222Rn (Fig. 2) constituting 75% and 60% of the total effective dose caused by all natural radionuclides for drilled-well u...

This paper describes an early-stage evaluation of a purpose-designed extraction/detection system that can be deployed by non-specialists either on-site or as part of a mobile laboratory. The system comprises three main components; (1) an optimised compact extraction system for recovery of radionuclides from the waste form; (2) an extraction test strip designed to recover the radionuclides from ...