apoptosis has a critical role in the pathogenesis of bleomycin induced-pulmonary fibrosis. the severity of fibrosis varies among different strains of mice. recent studies have indicated that expression of apoptotic regulatory genes may be specific in different cell types in various strains. in this study, bleomycin-induced pulmonary apoptosis in nmri albino mice were compared with c57bl/6 black...

Idiopathic pulmonary fibrosis is a lethal lung fibrotic disease, associated with aging mean survival of 2-5 years and no curative treatment. The GSE4 peptide able to rescue cells from senescence, DNA oxidative damage, inflammation, induces telomerase activity. Here, we investigated the protective effect expression in vitro rat alveolar epithelial (AECs), vivo bleomycin model fibrosis. Bleomycin...

Cystic fibrosis is a common genetic disorder characterized by a severe lung inflammation and fibrosis leading to the patient's death. Enhanced angiogenesis in cystic fibrosis (CF) tissue has been suggested, probably caused by the process of inflammation, as similarly described in asthma and chronic bronchitis. The present study demonstrates an intrinsic pro-angiogenic status of cystic fibrosis ...

results the administration of quercetin hydrate significantly reduced the concentration of il-13, pdgf-β, and tnf-α and increased the concentrations of inf-γ in balf. conclusions according to the experimental results, quercetin hydrate reduced the concentration of inflammatory fibrotic factors, such as il-13, pdgf-β, and tnf-α, and increased the level of the antifibrotic factor inf-γ, and the e...

ened, and useless alveolar walls of patients with lung fibrosis led investigators to think that the basic process leading to fibrosis was a sustained interstitial pneumonitis. Careful studies of animal models and humans over the last 15 years have revealed that, in fact, most pulmonary fibrosis begins in the alveolus and develops in definable stages over time (Figure 1): (a) epithelial cell inj...