The original online version of this article (Guo, R., Wang, X., Zhang, R., Shi, H., Qiao, Y., Yun, W., Ge, Lin, Y. and Lei, J. (2015) Response Subcutaneous Xenografts of Endometrial Cancer in Nude Mice to Inhibitors Phosphatidylinositol 3-Kinase/Akt Mitogen-Activated Protein Kinase (MAPK) Pathways: An Effective Therapeutic Strategy for Endometrial Cancer. Journal Therapy, 6, 1083-1092. htt...

In this study, we aimed to determine VEGFR-2, EGFR and PDGFR-β tyrosine kinase inhibitory activities of some pyrrolo[2,3-d]pyrimidine derivatives previously synthesized and showed potent cytotoxic and apoptotic effects against several cancer cell lines by our group and to evaluate the relationships between inhibitory activities and binding properties of the active compounds by molecular docking...

Cervical cancer belongs to the second most frequent kind of in female as well a major cause mortality all over world. MicroRNAs are crucial modulators multiple diseases. Based on GSE86100 database, microRNA-3137 expression was low cervical tissues and difference significant, thus we further probed potential along with mechanism cells. Reverse transcription-quantitative polymerase chain reaction...

The objective of this work was to identify novel downstream targets and evaluate the clinically interpretable significance long noncoding RNA KCNQ1OT1 expression in prognosis nasopharyngeal cancer. Patient with cancer (n=46) health volunteer (n=10) were collected from Beijing Army General Hospital (Beijing, China). Nasopharyngeal line 13-9B cells bought Chinese Academy Sciences Shanghai grown D...

The original online version of this article (Guo, R., Wang, X., Zhang, R., Shi, H., Qiao, Y., Yun, W., Ge, Lin, Y. and Lei, J. (2015) Response Subcutaneous Xenografts of Endometrial Cancer in Nude Mice to Inhibitors Phosphatidylinositol 3-Kinase/Akt Mitogen-Activated Protein Kinase (MAPK) Pathways: An Effective Therapeutic Strategy for Endometrial Cancer. Journal Therapy, 6, 1083-1092. htt...

Significant inhibition of Aurora B was achieved by the synthesis simplified fragments benzosceptrins and oroidin belonging to marine pyrrole-2-aminoimidazoles metabolites isolated from sponges. Evaluation kinase enabled discovery a synthetically accessible rigid acetylenic structural analogue EL-228 (1), whose structure could be optimized into potent CJ2-150 (37). Here we present new inhibitors...