Objective(s)Cutaneous leishmaniasis is a common parasitic disease which is endemic in some parts of the world. In vitro and in vivo studies have shown azithromycin efficacy on some Leishmania species. Because of structural similarity between clarithromycin and azithromycin and efficacy of clarithromycin against intracellular organisms and due to the absence of previous studies in this respect, ...

Background and objective: Leishmaniasis is caused by protozoa of Leishmania genus and can be considered as a Zoonosis. The desease has caused the world health problems with high endemicity in developing countries such as Iran. Various chemical drugs have been used for leishmaniasis treatment, but their side effects and drug resistance haveled to look for new effective compounds. Medicago lupuli...

Inorganic pyrophosphate promoted the acidification of an intracellular compartment in permeabilized promastigotes of Leishmania donovani, as measured by Acridine Orange uptake. The proton gradient generated by pyrophosphate was collapsed by addition of nigericin or NH4Cl. Pyrophosphate-driven proton translocation was stimulated by potassium ions, and inhibited by NaF, the pyrophosphate analogue...

The aim of this work is the in vitro and ex vivo assessment of the leishmanicidal activity of camptothecin and three analogues used in cancer therapy: topotecan (Hycantim®), gimatecan (ST1481) and the pro-drug irinotecan (Camptosar®) as well as its active metabolite SN-38 against Leishmania infantum. The activity of camptothecin and its derivatives was studied on extracellular L. infantum infra...

The dewaxed dichloromethane extract of Urolepis hecatantha and the compounds isolated from it were tested for their in vitro activity on Trypanosoma cruzi epimastigotes Leishmania infantum promastigotes. U. showed against both parasites with IC50 values 7 µg/mL 31 µg/mL, respectively. Fractionation led to isolation euparin, jaceidin, santhemoidin C, eucannabinolide. sesquiterpene lactones eucan...