Novel hybrids of lipoic acid and trolox connected through triamine spacers as well as analogues in which the lipoic acid was attached at different positions of the chroman moiety of vitamin E through an amide bond, were synthesized and exhibited strong inhibition of the microsomal lipid peroxidation. Moreover, the new molecules, at 1 microM concentration, reduced reperfusion arrhythmias and MDA...

Structural modifications were performed on the C-3 and C-28 positions of ursolic acid and oleanolic acid and the NO production inhibitory activities of the resulting derivatives were evaluated. The SAR revealed that the ursolic acid and oleanolic acid derivatives 3a and 4a, which possessing methoxy group at C-3 position exhibit improved NO production inhibitory activity on LPS-induced RAW247 ce...

In mobile applications such as eletric vehicles, weight and installation space are the primary limiting factors that affect system efficiency consequently driving range. Reusing machine windings of an electrical inductors, e. g. in DC-DC converters for onboard chargers, saves space. However, currents when operating converter can result undesired torque ripple generated by machine. Therefore, st...

A 6 0 is clinically the most important blood group system in transfusion medicine and includes many variant phenotypes. To understand the molecular genetic basis of this polymorphic system, we have analyzed genomic DNAs obtained from Japanese individuals possessing variant AB0 phenotypes including A,, Ax, A,,, cis-AB, B., and B-,. By polymerase chain reaction-single-strand conformation polymorp...

Phosphatidylinositol (PI) is distinct from other phospholipids, possessing a head group that can be modified by phosphorylation at multiple positions to generate unique signaling molecules collectively known as phosphoinositides. The set of kinases and phosphatases that regulate PI metabolism are conserved throughout eukaryotic evolution, and numerous studies have demonstrated that phosphoinosi...

documentary credit or letter of credit (lc) is one of the methods of payment in international commerce. the documentary credit is a binding commitment from the issuing bank to pay a sum of money to the beneficiary on certain conditions. the applicant needs to contract with an issuing bank to open a lc. the legal nature of such contract is a controversy issue and thus different opinions are brou...