for STDs and HIV.4 Though programs vary somewhat in their specific goals, most share the same premise: Expanded condom availability will increase the proportion of protected sexual encounters, particularly when it is accompanied by education and information about safer sex. Opponents have responded that distributing condoms in a school will legitimate and thus increase the prevalence of sexual ...

Any audio recording can be turned into a digital musical instrument by feeding it into an audio sampler. However, it is difficult to edit such a sound in musical terms or even to control it in real time with musical expression. This does not change much if a more sophisticated resynthesis method is applied. Many electronic musicians appreciate the direct and clear access to sound parameters a t...

The present study was planned to test the efficacy of Moringa oleifera on undesirable skin sebum secreted by sebaceous glands during winter season in humans. For this purpose, an extract of Moringa leaves was prepared due to strong antioxidant activity. 3% Moringa leaves extract was incorporated in active cream and the base was without extract. The study was conducted during the winter season (...

MIDI commands provide an abstract representation of audio in terms of note-on and note-off times, velocity, and controller data. The relationship of these commands to the actual audio signal is dependent on the actual synthesizer patch in use. Thus, it is hard to implement effects such as compression of the dynamic range or time correction based on MIDI commands alone. To improve on this, we ha...

A major concern for transdermal drug delivery systems is the low bioavailability of targeted drugs primarily caused by the skin’s barrier function. The resistance to the carrier matrix for the diffusion and transport of drugs, however, is routinely ignored. This study reports a promising and attractive approach to reducing the resistance to drug transport in the carrier matrix, to enhance drug ...

Efforts to improve the oral bioavailability of cyclosporine A (CyA) remains a challenge in the field of drug delivery. In this study, glyceryl monooleate (GMO)/poloxamer 407 cubic nanoparticles were evaluated as potential vehicles to improve the oral bioavailability of CyA. Cubic nanoparticles were prepared via the fragmentation of a bulk GMO/poloxamer 407 cubic phase gel by sonication and homo...

The morbidity rate of hypertriglyceridemic acute pancreatitis (HTG-AP) increased rapidly over the last decade. However an appropriate animal model was lacking to recapitulate this complicated human disease. We established a novel mice model of HTG-AP by poloxamer 407 (P-407) combined with caerulein (Cae). In our study, serum triglyceride levels of P-407 induced mice were elevated in a dose-depe...

Objective: In current research, solid lipid nanoparticles (SLN) are formulated for the anticancer drug, nilotinib, to conquer drawbacks associated with drug including low bioavailability and solubility. Methods: The formulation comprised of tripalmitin (lipid), poloxamer 188(surfactant) glyceryl palmitostearate (cosurfactant) by solvent evaporation technique. process variables SLN were optimize...

Liquid antisolvent process was explored as a solubility modulating tool. Bicalutamide, a poorly water soluble drug, was used as a candidate. Low aqueous solubility and poor dissolution of bicalutamide results into poor and variable bioavailability. Therefore, the objective of the present work was to modify the solubility of bicalutamide using the liquid antisolvent precipitation process. HPMC E...