BACKGROUND This study evaluated potential correlations between the allele burden of the Janus kinase 2 (JAK2) V617F mutation and clinicohematologic characteristics in patients with myeloproliferative neoplasms (MPN). METHODS Clinical and hematologic features were reviewed for 103 MPN patients, including patients with polycythemia vera (PV, 22 patients), essential thrombocythemia (ET, 64 patie...

Preliminary studies have shown that orange peel polymethoxylated flavones (PMFs) exhibit beneficial biological properties in animals. These properties have increased the demands for these compounds as candidate nutraceuticals and specialty food ingredients. Orange oil residues are a likely commercial source of the PMFs, and a rapid, solvent-free method for the analysis of the PMFs in orange oil...

Many existing approaches to collaborative filtering can neither handle very large datasets nor easily deal with users who have very few ratings. In this paper we present the Probabilistic Matrix Factorization (PMF) model which scales linearly with the number of observations and, more importantly, performs well on the large, sparse, and very imbalanced Netflix dataset. We further extend the PMF ...

We evaluated comparatively the mechanical strength in three kinds of surgical fixation techniques for canine atlantoaxial joint. Atlantoaxial plate fixation (APF), polymethylmethacrylate (PMMA) fixation (PMF) and transarticular fixation (TAF) were applied to the atlas and axis harvested from healthy beagle dogs, and then, the specimens were tested. The PMF group had significantly higher resista...

Protected from host immune attack and antibiotic penetration by their unique cell envelope, mycobacterial pathogens cause devastating human diseases such as tuberculosis. Seamless coordination of cell growth with cell envelope elongation at the pole maintains this barrier. Unraveling this spatiotemporal regulation is a potential strategy for controlling mycobacterial infections. Our biochemical...

Progressive massive fibrosis (PMF) is a chronic interstitial lung disease with a complex aetiology that can occur after cumulative dust exposure. A case-control study was conducted to test the hypothesis that single nucleotide polymorphisms (SNPs) within genes involved in inflammatory and fibrotic processes modulate the risk of PMF development. The study population consisted of 648 underground ...

An in-line Mach–Zehnder-interferometer-based two-dimensional (2-D) micrometric displacement sensor was fabricated by inserting a polarization maintaining fiber (PMF) with a length of 1 cm between two conventional singlemode fibers (SMFs). The left end of the PMF was mismatch fusion spliced with an SMF. The right end of the PMF was connected to another SMF without fusion splicing. Two independen...

Hidden Markov fields (HMF), which are widely applied in various problems arising in image processing, have recently been generalized to Pairwise Markov Fields (PMF). Although the hidden process is no longer necessarily a Markov one in PMF models, they still allow one to recover it from observed data. We propose in this paper two original methods of parameter estimation in PMF, based on general ...

We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia myelofibrosis (post-PV/ET MF). Fifty-eight subjects had ≥1 non-driver mutation upon diagnosis. Mutations in mRNA splicing genes, especially in U2A...

Natural sources of hydrocolloids may serve as healthier alternatives to modified gluten replacement in gluten-free food products. In this study, the physicochemical, antioxidant and starch-digesting enzymes inhibitory properties whole pearl millet flour (PMF) blended with 1.5% 3% either sweet detar (SDF, a natural source hydrocolloids) or sodium carboxymethyl cellulose (SCMC, hydrocolloid), sen...