نتایج جستجو برای: pla2 antigen

تعداد نتایج: 201520  

Journal: :Maedica 2010
Manole Cojocaru Inimioara Mihaela Cojocaru Isabela Silosi

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a predictor biomarker for incident atherosclerotic disease. Lp-PLA2 has been identified in atherosclerotic plaques, however, its role in atherosclerosis is still under investigation. Lp-PLA2 belongs to the superfamily of phospholipase A2 enzymes. It is produced by macrophages that appears to play a role in the atherosclerotic vessel wall. Eme...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1991
D Piomelli P Greengard

In preparations of synaptic terminals (synaptosomes) isolated from rat brain, the activity of phospholipase A2 (PLA2), a phospholipid hydrolase that serves a central function in signal transduction, was inhibited in a Ca(2+)-dependent manner by incubation with 60 mM K+ or with the Ca(2+)-selective ionophore ionomycin. Reversal by alkaline phosphatase treatment suggested that this inhibitory eff...

2015
Anping Cai Guang Li Jiyan Chen Xida Li Liwen Li Yingling Zhou

BACKGROUND Lipoprotein-associated phospholipase A2 (Lp-PLA2) plays complex and adverse roles on atherosclerosis. Current study was to investigate whether increased plasma Lp-PLA2 level is independently associated with the severity of coronary artery diseases (CAD). METHODS Totally 781 participants were enrolled and performed coronary angiography (CAG) to figure out the number of coronary arte...

Journal: :The Journal of biological chemistry 1998
R S Koduri S F Baker Y Snitko S K Han W Cho D C Wilton M H Gelb

Human group IIa phospholipase A2 (hIIa-PLA2) is a highly basic protein that is secreted from a number of cells during inflammation and may play a role in arachidonate liberation and in destruction of invading bacteria. It has been proposed that rodent group IIa PLA2 is anchored to cell surfaces via attachment to heparan sulfate proteoglycan and that this interaction facilitates lipolysis. hIIa-...

Journal: :Circulation 2004
Christie M Ballantyne Ron C Hoogeveen Heejung Bang Josef Coresh Aaron R Folsom Gerardo Heiss A Richey Sharrett

BACKGROUND Measuring C-reactive protein (CRP) has been recommended to identify patients at high risk for coronary heart disease (CHD) with low LDL cholesterol (LDL-C). Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a proinflammatory enzyme associated primarily with LDL. METHODS AND RESULTS In a prospective, case cohort study in 12 819 apparently healthy middle-aged men and women in the ...

ژورنال: :مجله علمی دانشگاه علوم پزشکی رفسنجان 0
بتول پورقیصری b. pourgheysari pathology and hematology department, shahrekord university of medical sciences, shahrekord, iranشهرکرد، دانشگاه علوم پزشکی شهرکرد، گروه پاتولوژی و هماتولوژیسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهرکرد (shahr kord university of medical sciences) علی هاشمی نیا a. hasheminia cellular and molecular research center, shahrekord university of medical sciences, shahrekord, iranشهرکرد، دانشگاه علوم پزشکی شهرکرد،مرکز تحقیقات سلولی و مولکولیسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهرکرد (shahr kord university of medical sciences) حمید روحی بروجنی h. rouhi-boroujeni3 دانشیار گروه آموزشی داخلی، مرکز تحقیقات بیوشیمی بالینی، دانشگاه علوم پزشکی شهرکردسازمان اصلی تایید شده: دانشگاه علوم پزشکی شهرکرد (shahr kord university of medical sciences)

gte vml 1]> چکیده زمینه و هدف: ترومبوآمبولی وریدی (vte) از علل مهم مرگ و میر در جوامع مختلف بشری است. فاکتور 5 لیدن (fvl)، پلی مورفیسم c677t در متیلن تتراهیدروفولات ردوکتاز (mthfr) و پلی مورفیسم a2 از گلیکوپروتئین iib/iiia پلاکتی از عوامل مهم خطرزای ارثی در ترومبوآمبولی وریدی است. از آن جا که اطلاعات معدودی از هموزیگوت ها در دست است، هدف از مطالعه حاضر بررسی همراهی حالت هموزیگوت پلی مورفیسم های...

2012
Robert T Cormier

Description Background: The phospholipase A2 (PLA2s) superfamily, consisting of at least 34 members subdivided into at least 15 groups, is a group of intracellular and secreted enzymes that hydrolyzes the sn-2 ester bond in glycerophospholipids found in lipoproteins and cellular membranes to liberate fatty acids and lysophospholipids that can act as intracellular second messengers or are furthe...

Journal: :Biochimica et biophysica acta 2015
Narine A Ghazaryan Lusine Ghulikyan Arsen Kishmiryan Tatyana V Andreeva Yuri N Utkin Victor I Tsetlin Bruno Lomonte Naira M Ayvazyan

We describe the interaction of various phospholipases A2 (PLA2) from snake venoms of the family Viperidae (Macrovipera lebetina obtusa, Vipera ursinii renardi, Bothrops asper) with giant unilamellar vesicles (GUVs) composed of natural brain phospholipids mixture, visualized through fluorescence microscopy. The membrane fluorescent probes 8-anilino-1-naphthalenesulfonicacid (ANS), LAUDRAN and PR...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2005
Andrew Zalewski Colin Macphee

The development of atherosclerotic vascular disease is invariably linked to the formation of bioactive lipid mediators and accompanying vascular inflammation. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an enzyme that is produced by inflammatory cells, co-travels with circulating low-density lipoprotein (LDL), and hydrolyzes oxidized phospholipids in LDL. Its biological role has been c...

2015
Rachelle S. Doody Jasenka Demirovic Christie M. Ballantyne Wenyaw Chan Robert Barber Suzanne Powell Valory Pavlik

INTRODUCTION Lipoprotein-associated phospholipase A2 (Lp-PLA2) and homocysteine (Hcy) have been linked to inflammation and Alzheimer's disease (AD). Using a case-control design, we examined their independent effects and interactions with cardiovascular disease equivalent (CVDE), on AD risk. METHODS AD cases and controls were from the Texas Alzheimer's Research and Care Consortium study. Lp-PL...

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