background :the cag pathogenicity island includes a number of genes, including cytotoxin-associated protein a (caga) and vacuolatingcytotoxin (vaca) genotypes, which are associated with bacterial virulence. although the role of caga and vaca in the virulence of helicobacter pylori (h. pylori) is well-established in epidemiological studies, the relationship between the caga and vaca genotypes in...

BACKGROUND AND AIMS The genetic trait plays a part in the pathogenesis of peptic ulcer disease. To identify a DNA marker for peptic ulcer disease, the association between the restriction fragment length polymorphism (RFLP) of the pepsinogen C (PGC) gene and peptic ulcer disease was investigated. PATIENTS AND METHODS One hundred and seventy seven unrelated controls, 75 patients with gastric ul...

For more than a century, peptic ulcer disease has been a major cause of morbidity and mortality. In the early part of the 20th century, when stress and diet were judged to be important pathogenetic factors for peptic ulceration, patients with peptic ulcers were treated with hospitalization, bed rest, and the prescription of “bland” diets. By the 1950s, investigators and clinicians had focused t...

The Development and Assessment of a Herbal Floating Tablet for Peptic Ulcer Disease. goal creating herbal floating tablet is to extend the drugs duration in gastrointestinal tract. This will increase bioavailability result greater absorption than with convectional dose form. Due its gastro-retentive feature, medicine remains at site inflammation longer amount time, resulting more targeted actio...

The following case of perforated duodenal ulcer in an infant is reported, not only on account of the raritv of the condition, but also because the symptoms and course presented differ somewhat from those in previouslv reported cases. Peptic ulcers are evidently not very rare in infants under one year of age, but onlv a few have been recorded in England. In Welch's1 collection of 6074 cases of p...

BACKGROUND The association between stress and peptic ulcers has been questioned since the discovery of helicobacter pylori. This study examined whether high perceived everyday life stress was associated with an increased risk of either receiving a triple treatment or being diagnosed with a peptic ulcer. METHODS Cohen's perceived stress scale measured the level of stress in a general health su...

introduction: helicobacter pylori infections occur in about 50% of the world population and have a main role in the creation of peptic ulcer and its related cancer. we sought to evaluate the effectiveness of two treatment regimens on the eradication of helicobacter pylori and its complications among peptic ulcer patients. materials and methods: by a clinical trial, patients with peptic ulcer sh...

background : many  helicobacter pylori strains express adhesin proteins that bind to specific  host-cell  macromolecule  receptors,  like sialic acid binding adhesion ( saba ).    saba-expressing  strains have been associated with gastric cancer  and  negatively  associated   with  duodenal   ulcers. the  aim  of  this study  was  to  determine   the  status  of   saba   gene  of   h.  pylori  ...

The prevalence of active and inactive peptic ulcer was 23% in male workers aged 31-60 at a plastics processing factory in Tokyo. Similarly, the incidence of active and inactive peptic ulcer during one year was 5% or more. The findings from a case control study suggested that smoking and family history were the major aetiological factors. The incidence and prevalence of peptic ulcer in male fact...

Peptic ulcer bleeding is an internal medical emergency. Endoscopic hemostasis has been shown to improve the survival rate of patients with peptic ulcer bleeding. Although the established hemostatic modalities, including injection, thermal therapy, and mechanical therapy, are effective in controlling peptic ulcer bleeding, hemostasis can be difficult to achieve in some cases. As a result, recent...