نتایج جستجو برای: pde3a
تعداد نتایج: 120 فیلتر نتایج به سال:
A recent large-scale meta-analysis of genome-wide studies has identified 95 loci, 59 of them novel, as statistically significant predictors of blood lipid traits; we tested whether the same loci explain the observed heterogeneity in response to lipid-lowering therapy with fenofibrate. Using data from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN, n = 861) we fit linear mixed mode...
BACKGROUND Formation of blood vessels requires the concerted regulation of an unknown number of genes in a spatial-, time- and dosage-dependent manner. Determining genes, which drive vascular maturation is crucial for the identification of new therapeutic targets against pathological angiogenesis. METHODOLOGY/PRINCIPAL FINDINGS [corrected] We accessed global gene regulation throughout maturat...
The phosphodiesterase (PDE)--opathies are disorders caused by mutations in the 21-member family of human genes encoding enzymes that hydrolyze cyclic nucleotides cAMP and/or cAMP. PDEs an important and expanding set targets for drug development.The various PDE-opathies remarkably diverse, with phenotypes varying from development/neoplasia (e.g., PDE8 PDE11), to cardiovascular system (PDE3) bone...
Following early embryonic germ cell migration, oocytes are surrounded by somatic cells and remain arrested at diplotene stage until luteinizing hormone (LH) surge. Strict regulation of both meiotic arrest and meiotic resumption during dormant stage are critical for future fertility. Inter-cellular signaling system between the somatic compartment and oocyte regulates these meiotic events and det...
Cyclic nucleotides (cAMP and cGMP) are the main second messengers linked to vasodilatation. They are synthesized by cyclases and degraded by different types of phosphodiesterases (PDE). The effect of PDE inhibition and cyclases stimulation on 5-hydroxytryptamine (5-HT; 1 microM) and histamine (10 microM) contracted arteries was analysed. Stimulation of guanylate cyclase or adenylate cyclase rel...
We have used reverse transcriptase PCR, platelet mRNA and degenerate primers based on platelet peptide sequences, to amplify a fragment of platelet cGMP-inhibited phosphodiesterase (cGI-PDE; PDE3). Sequence analysis of this clone established that both the platelet and the cardiac forms of PDE3 were derived from the same gene (PDE3A). A RT-PCR product representing the C-terminal half of platelet...
The concentration of cyclic AMP within cells is regulated by the activities of adenylyl cyclases and phosphodiesterases (PDE) and the receptors and G proteins that modulate their activities. The extent to which cyclic AMP accumulates in a given cell and activates protein kinase A (PKA) is subject to tight transcriptional and post-transcriptional autoregulation (Table 1). For example, cyclic AMP...
We carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10−11 to 5.0 × 10−21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple ne...
W hen a basic scientist looks at heart failure, he sees a disease that appears to originate from any damage that causes low cardiac output, is progressive, and elicits a variety of physiological responses that attempt to correct the depressed cardiac function. Furthermore, these reflex physiological responses to low cardiac output—increased sympathoadrenal tone, increased activity of the renin–...
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