Alpha synuclein (SNCA) genes and environmental factors are important risk factors of Parkinson's disease (PD). The agrichemicals paraquat, maneb and chlorpyrifos selectively target dopaminergic neurons, leading to parkinsonism, through ill-defined mechanisms. We analyzed the ability of low dose paraquat, maneb and chlorpyrifos, separately or combined together, to induce synucleinopathy in wild ...

Paraquat and diquat are classified as bipyridyl compounds not only leads to acute organ damage, but also to a variety of complications. Patients with severe paraquat-induced poisoning may succumb to multiple organ failure involving the circulatory and respiratory systems. Deliberate self-poisoning with paraquat continues to be a major public health concern in many developing countries. At prese...

The aim of the present study was to show the abilities of captopril as a thiol ACEi (angiotensin converting enzyme inhibitor), on mitochondria toxicity due to paraquat. Mitochondrial isolation from rat liver was divided into 4 groups. Group 1 was considered as control, group 2 received paraquat (5 mM), group 3 received captopril (0.08 mM) and group 4 received paraquat (5 mM)+captopril (0.08 mM)...

Poisoning by pesticides and other agricultural chemicals is a major public health problem worldwide, especially in developing countries. Globally, there are about 20,000 annual fatalities and more than 2 million hospitalizations due to poisoning by pesticides and agricultural chemicals.1 There were approximately 340,000 cases of agricultural and horticultural poisoning reported in the United St...

McDonagh, B. J., and Martin, J. (1970). Archives of Disease in Childhood, 45, 425. Paraquat poisoning in children. Four children with paraquat poisoning are described, with 2 fatalities. In one fatal case delay in treatment occurred as the nature of the ingested fluid was uncertain. A method for rapid detection of paraquat in the urine is referred to. The treatment of paraquat poisoning consist...

Paraquat is highly toxic to human and is widely used in agriculture as a contact herbicide. However, it is easily accessible in agricultural product shops. Seven cases of paraquat poisoning were treated in Tuen Mun Hospital from 1998-2005. The mortality (4 out of 7) was very high. One patient died after oral exposure to paraquat despite immunosuppressive and antioxidant therapies. The mechanism...

BACKGROUND The study aimed to investigate the therapeutic benefits of intravenous Xuebijing on acute kidney injury (AKI) in rats with paraquat intoxication. METHODS Male Sprague-Dawley rats were randomly divided equally into three groups: sham group (n=8), paraquat group (n=8) and Xuebijing-treated group (n=8) using a random number table. The rats were intraperitoneally injected with 50 mg/kg...

Microsomal fractions were prepared from the liver of rabbits to investigate the effects of paraquat (methyl viologen) on generation of metabolites of halothane under the optimal aerobic and anaerobic conditions. Halothane (CF3CHClBr) is known to undergo oxidative and reductive biotransformation in the hepatic mixed function oxidase system including cytochrome-P450 reductase and cytochrome P450....

background: paraquat is nonselective bipyridyl herbicide that induces hepatotoxicity through oxidative stress. vitamin c and chitosan have antioxidant as well as radical scavenger properties and show protective effects against reactive oxygen species (ros). in the present study, hepatoprotective effects of chitosan and vitamin c were evaluated in common carp exposed to paraquat. methods: while ...