Papaverine Hydrochloride and Experimental Hemorrhagic Cerebral A rterial Spasm • Chronic hemorrhagic spasm of the basilar artery was produced in beagle dogs by introducing blood into the cisterna magna. Spasm was evaluated by means of vertebral angiography. Papaverine hydrochloride was administered intravenously, intracisternally as well as intra-arterially. The intracisternal route was the mor...

To evaluate the factors contributing to the decline in erectile function with age, we performed measurement of nocturnal penile tumescence (NPT) and penile vascular examinations in 407 men. The following results were obtained. 1) The penile circumferential increment during NPT measured by an erectometer was gradually decreased with age, especially markedly after 60 years of age. The percentage ...

Objective: To investigate whether blood flow in normal and post-stenotic coronary arteries is altered by therapeutic doses of the sulfonylurea agent glibenclamide. Patients: 12 patients with a high grade stenosis of the left anterior descending coronary artery (n = 10) or left circumflex coronary artery (n = 2), and an angiographically normal corresponding left circumflex artery or left anterio...

Recent evidence indicates that elevated plasma levels of homocysteine are a risk factor for ischemic cerebrovascular diseases. However, little is known about cerebrovascular effects of homocysteine. Homocysteine could impair cerebrovascular function by metal-catalyzed production of activated oxygen species. We studied whether homocysteine, in the presence of Cu2+, alters reactivity of cerebral ...