The present investigation deals with the formulation, optimization and evaluation of sodium alginate based floating oral In situ gel of Pantoprazole. Sodium alginate used as a polymer and Calcium carbonate was used as a crosslinking agent. In-situ forming polymeric formulation drug delivery systems is in sol form before administration in the body, but once administered, undergoes gelation in-si...

Objective: Famotidine is an H2 receptor antagonist (H2RA) and has been shown to have antiviral properties in in-vitro studies. Pantoprazole one of the proton pump inhibitors (PPI). In this study, it was aimed compare efficacy with treatment COVID-19.
 Material-method: Patients who were hospitalized given famotidine pantoprazole for at least 48 hours included study. Demographic, clinical la...

Although proton pump inhibitors are widely used, allergic reactions to this group of drugs are rarely reported. In this paper we present the case of a patient who developed a delayed reaction to pantoprazole. A 35-year-old female patient complained of generalised erythema with intense itching and desquamation for three weeks before consulting (Fig. 1). The rash was first noticed five days after...

background the prevalence of peptic ulcer disease in hemodialysis patients is more than the general population. they are also more prone to complications including upper gastrointestinal bleeding. the aim of this study was to compare the efficacy of 14 days hybrid regimen with 14 days triple therapy for helicobacter pylori ( h . pylori ) eradication in hemodialysis patients. methods forty hemod...

Although rare, anaphylactic reactions induced by proton pump inhibitors have been reported. The presence of cross-reactivity between different members of the group is not clear. We studied 9 patients with adverse reactions to omeprazole. Clinical symptoms appeared immediately in 8 patients and after 4 hours in 1. Symptoms ranged from urticaria/angioedema in 7 cases to anaphylaxis in 2 cases. Sk...