Diabetes mellitus is a group of metabolic disorders, characterized by defects in insulin secretion, insulin action or both. The synthetic oral drugs are used for treatment of diabetes. These drugs are associated with number of side effects. Management of diabetes withought any side effect is still challenge to medical system. Present work aimed to evaluate hypoglycemic and antioxidant potency o...

Garlic (Allium sativum L., Alliaceae), Persian shallot (Allium ascalonicum L., Alliaceae ) and Sage (Salvia officinalis L., Lamiaceae) are believed to have hypoglycemic properties and have been used traditionally as antidiabetic herbal medicines in Iran. In this study, diabetes was induced by subcutaneous injection of alloxan monohydrate (100 mg kg−1) to male Wistar rats. Antidiabetic effects of...

Diabetes mellitus is known as metabolic disorder related to glucose intolerance which is characterized by hyperglycemia. Diabetes mellitus can be treated by insulin and oral hypoglycemic agents. Most of known oral hypoglycemic are peroxisome proliferatoractivated receptors (PPAR) agonist. There are three different subtypes of PPARs are identified and they are involved in glucose metabolism. A b...

The objective of the study is to evaluate the hypoglycemic activity of Barringtonia acutangula (BA) fruit extracts i.e. aqueous, methanol and chloroform in streptozotocin (STZ) 50mg /kg induced hyperglycemic Wistar rats. In addition, the effect off all the three extracts of BA fruit on oral glucose tolerance in glucose loaded normal rats was also determined. Aqueous extract (400 mg/kg) treatmen...

BACKGROUND Little or no research has determined the effect of vitamin D3 supplementation in conjunction with pharmacological and non-pharmacological approaches in the diabetes mellitus type 2 (DMT2) patients. The objective of this study was to determine the effect of vitamin D3 supplementation in a cohort of Saudi DMT2 population on diet, insulin and/or different oral hypoglycemic agents and co...

OBJECTIVE The overall goal of the study was to evaluate the probable reasons for patients' nonadherence to prescribed oral hypoglycemic medications in an ambulatory care setting in Nigeria with a view to identifying points for necessary intervention to improve adherence and treatment outcomes. Also, the recommended non-drug management options for diabetes patients with emphasis on self monitori...

BACKGROUND The available drugs for diabetes, Insulin or Oral hypoglycemic agents have one or more side effects. Search for new antidiabetic drugs with minimal or no side effects from medicinal plants is a challenge according to WHO recommendations. In this aspect, the present study was undertaken to evaluate the antihyperglycemic and antihyperlipidemic effects of Piper longum root aqueous extra...

BACKGROUND Glucagon-like peptide-1 (GLP-1) (7-36) is a peptide incretin hormone released from the endocrine L-cells of the intestinal mucosa with unique antidiabetic potential. Due to low absorption efficiency and instability in the gastrointestinal tract, the introduction of orally active GLP-1 is a large challenge. Here we developed a novel silica-based pH-sensitive nanomatrix of GLP-1 (SPN-G...

www.pharmacypractice.org (ISSN: 1886-3655) 163 ABSTRACT Objective: The overall goal of the study was to evaluate the probable reasons for patients’ nonadherence to prescribed oral hypoglycemic medications in an ambulatory care setting in Nigeria with a view to identifying points for necessary intervention to improve adherence and treatment outcomes. Also, the recommended non-drug management opt...