The liver is susceptible to toxic effects, as it the main site of acrylamide biotransformation and detoxification. Researchers have claimed that placental growth factor (PlGF) its pathway are potentially involved in numerous diseases, including fibrosis angiogenesis. Oleuropein a natural phenolic compound with potent antioxidant effects. purpose this study was examine role PlGF potential protec...

The Mediterranean diet, which is abundant in antioxidants, is associated with a relatively low incidence of coronary heart disease. Olive oil and olives, which contain the antioxidants hydroxytyrosol, oleuropein, and tyrosol, are important components of this diet. In this study, the effects of oxidative stress on the nitric oxide radical (NO(*))-mediated relaxation of rat aorta and the protecti...

Virgin olive oils from the fruits of Croatian autochthonous varieties Oblica, Lastovka and Levantinka were characterized for the first time. Headspace volatiles were analyzed by HS-SPME/GC-FID/MS. The main volatiles were C6 compounds. The most abundant was (E)-hex-2-enal (62.60%-69.20%). (Z)-Hex-3-enal was not found in Lastovka oil, while Levantinka oil did not contain hexanal. Tocopherols, chl...

OBJECTIVE Epidemiology suggests that Mediterranean diets are associated with reduced risk of cardiovascular disease. Because monocyte adhesion to the endothelium is crucial in early atherogenesis, we evaluated whether typical olive oil and red wine polyphenols affect endothelial-leukocyte adhesion molecule expression and monocyte adhesion. METHODS AND RESULTS Phytochemicals in olive oil and r...

In this study, ultrasonic-assisted matrix solid-phase dispersion (UA-MSPD) as a new sample preparation method for natural product analysis was developed. Influential parameters of the UA-MSPD method was optimized using oleuropein content of olive leaves as a model analyte. Main parameters of the proposed technique such as ultrasonic time, amplitude and pulse, sorbent material, the ratio of samp...

Oleuropein, Hydroxytyrosol and Tyrosol are three major phenolic compounds present in olive with remarkable pharmacological effects. In this study, leaves and fruit of four olive cultivars including ‘Fishomi’, ‘Mary’, ‘Roghani’ and ‘Zard’ grown in the north of Iran were collected for comparative evaluation of the concentration of Oleuropein, Hydroxytyrosol and Tyrosol as well as antioxidant prop...

The production of olive oil generates massive quantities of by-product called olive mill wastewater (OMWW). The uncontrolled disposal of OMWW poses serious environmental problems. The OMWW effluent is rich in several polyphenolic compounds. Liquid-liquid extraction of OMWW using ethyl acetate solvent was used to enrich phenolic compounds under investigation. Total phenolic and flavonoid content...