The neurobehavioral profile of anti-epileptic drugs (AEDs) has been a recurrent research topic in the scientific literature. As pharmacological treatments for epilepsy continue to evolve, there is a general consensus that newer AEDs have less detrimental side effects in comparison to their older counterparts. Among newer AEDs and epilepsy patients, potential risk for neurobehavioral changes has...

BACKGROUND The Jerusalem Infant Development Study is a prospective investigation comparing offspring of schizophrenic parents with offspring of parents who have no mental disorder or have nonschizophrenic mental disorders. During infancy and school age, a subgroup of offspring of schizophrenic parents showed global neurobehavioral deficits that were hypothesized to be indicators of vulnerabilit...

The effect of aqueous extract of Cecropia glazioui Snethlage (Embauba) in the rat fetal development. This study was to complement previous assays on the physical and neurobehavioral development of rats resulted from oral administration of 1 g/kg/day Cecropia glazioui Snethlage (C. glazioui) aqueous extract (LD50 > 5 g·kg) in pregnant rats (periand post-natal studies). In the present study, the ...

Outbreaks of methylmercury poisoning in Japan and Iraq have demonstrated the sensitivity of the fetus to neurotoxic effects. Based on toxicokinetics and considerations of practicability, the optimal biomarker of methylmercury exposure is the hair concentration, but whole-blood measurements of mercury are also useful. Dose-response relations are still incompletely known, especially concentrating...