Neomorphic transformations in isocitrate dehydrogenase 1 (IDH1) are the key mutations prevalently found various cancers including glioma. Recently identified mIDH1 specific inhibitors showed modest brain penetrating potential and dose-limiting toxicity. Herein, we elucidate virtual screening strategies to discover persuasive from approved subset of DrugBank database consisting 2715 molecules. I...

gait contains important information about the status of the human body and physiological signs. in many medical applications, it isimportant to monitor and accurately analyze the gait of the patient. since walking shows the reproducibility signs in several phases,separating these phases can be used for the gait analysis. in this study, a method based on image processing for extracting phases of...

The molecular mechanisms underlying general anesthesia are unknown. For volatile general anesthetics (VAs), indirect evidence for both lipid and protein targets has been found. However, no in vivo data have implicated clearly any particular lipid or protein in the control of sensitivity to clinical concentrations of VAs. Genetics provides one approach toward identifying these mechanisms, but ge...

Transcription factor control of cell-specific downstream targets can be significantly altered when the controlling factor is mutated. We show that the semi-dominant neonatal anemia (Nan) mutation in the EKLF/KLF1 transcription factor leads to ectopic expression of proteins that are not normally expressed in the red blood cell, leading to systemic effects that exacerbate the intrinsic anemia in ...

It is agued that there is crosslinguistic variation regarding what counts as a phase in the traditional Noun Prase (TNP) which tracks independent crosslinguistic variation regarding the categorial status of the TNP assumed under the DP/NP parameter, on which languages without articles lack DP. In particular, it is argued that DP is a phase in DP languages, and NP is a phase in NP languages. How...

These lecture notes are meant to provide a pedagogical introduction, and present the latest theoretical and experimental developments on the physics of vortices in type II superconductors. 1 Why and what in vortices The discovery of high Tc superconductors has shattered the comforting sense of understanding that we had of the phase diagram and physical properties of type II superconductors, and...

Two-d imens iona l l a y e r s of charges t r a p p e d a t t h e b o u n d a r i e s between t h e v a r i o u s h e l i u m phases s t r o n g l y i n t e r a c t w i t h t h e s e i n t e r f a c e s a t h i g h e l e c t r i c f i e l d s . The c o u p l i n g , w h i c h l e a d s t o an e l e c t r o h y d r o d y n a m i c i n s t a b i l i t y , p r o v i d e s new methods f o r s t u d...