A previously healthy 40-year-old male was admitted to investigate the second episode of an acute flaccid paralysis that occurred within 3 months. Both began suddenly in the early morning as generalized weakness evolving to paralysis within 2 h, and sparing respiratory and facial muscles. The paralysis was painless, and there was no disturbance of consciousness. Vital signs, including heart rate...

spinal muscular atrophy (sma) is a genetic disorder which affect nervous system and is characterized with progressive distal motor neuron weakness. the survival motor neuron (smn) protein level reduces in patients with sma. two different genes code survival motor neuron protein in human genome. skeletal and intercostal muscles denervation lead to weakness, hypotony, hyporeflexia, respiratory fa...

We present a young Thai man who developed acute flaccid paralysis after receiving pulse methylprednisolone for chronic inflammatory demyelinating polyneuropathy. Hypokalemia from intracellular shift was confirmed by calculation of transtubular potassium gradient (TTKG). His muscle strength and serum potassium fully recovered with a small amount of potassium replacement. Graves' disease was subs...

Hypokalaemic periodic paralysis secondary to subclinical hyperthyroidism is an uncommon clinical phenomenon characterised by lower limb hypokalaemia in the background of hyperthyroidism. In this article, we report a patient who presented with progressive muscle weakness that was refractory potassium replacement therapy. He has no diarrhoea, reduced appetite and not taking any medication can cau...

Abstract Over the last two decades, senior author (B.H.) has had an extensive experience with facial paralysis reconstruction. During this period, techniques have evolved substantially based on and after observing analyzing surgical outcomes. The purpose of article is to relay lessons learned from 20 years' suggest algorithm. In retrospective study, we included 343 cases cases. Complete were 28...

Spinal muscular atrophy (SMA) is a genetic disorder which affect nervous system and is characterized with progressive distal motor neuron weakness. The survival motor neuron (SMN) protein level reduces in patients with SMA. Two different genes code survival motor neuron protein in human genome. Skeletal and intercostal muscles denervation lead to weakness, hypotony, hyporeflexia, respiratory fa...

Facial paralysis is a devastating condition with a severe emotional impact on patients as it significantly affects appearance and impairs function. Patients complain of not being able to hold food and liquid in their mouth, not being able to speak clearly, and not being able to smile. T h e i n a b i l i t y t o s m i l e i s o f t e n psychologically troubling to patients. This presents a chal...

Hypokalemic periodic paralysis (hypoKPP) is characterized by episodic flaccid paralysis of muscle and acute hypokalemia during attacks. Familial forms of hypoKPP are predominantly caused by mutations of either voltage-gated Ca(2+) or Na(+) channels. The pathogenic gene mutation in non-familial hypoKPP, consisting mainly of thyrotoxic periodic paralysis (TPP) and sporadic periodic paralysis (SPP...

BACKGROUND Primary periodic paralyses are rare inherited muscle diseases characterised by episodes of flaccid weakness affecting one or more limbs, lasting several hours to several days, caused by mutations in skeletal muscle channel genes. OBJECTIVES The objective of this review was to systematically review treatment of periodic paralyses. SEARCH STRATEGY We searched the Cochrane Neuromusc...

OBJECTIVES/HYPOTHESIS Vocal fold paresis and paralysis are common conditions. Treatment options include augmentation laryngoplasty and voice therapy. The optimal management for this condition is unclear. The objective of this study was to assess possible neuromuscular compensation mechanisms that could potentially be used in the treatment of vocal fold paresis and paralysis. STUDY DESIGN In v...