Neurons in the medial temporal lobe (MTL) respond selectively to pictures of specific individuals, objects, and places. However, the underlying mechanisms leading to such degree of stimulus selectivity are largely unknown. A necessary step to move forward in this direction involves the identification and characterization of the different neuron types present in MTL circuitry. We show that putat...

Cognitive scientists have used developments in functional imaging to explore the role of the medial temporal lobe (MTL) in memory formation. Lesion studies have suggested that separate MTL subregions make distinct contributions to memory. Functional imaging of these distinct contributions, however, remains a challenge, because the proximity of the MTL substructures tests the spatial resolution ...

This paper describes experiments done to demonstrate the effectiveness of Multi-task Learning (MTL) for software agents. The experiments were carried out on an agent for processing electronic mail (email). MTL is shown to slightly improve the learning rate in this domain over Single-task Learning (STL) in a k-nearest-neighbor implementation. We then introduce a new method of lazy learning we ca...

The MIT Microsystems Technology Laboratories (MTL) is an interdepartmental laboratory with a mission to foster research and education in semiconductor process and device technology and in integrated circuits and systems design. MTL provides microand nanofabrication and computer-aided design (CAD) infrastructure to the entire campus. MTL has 30 core faculty members who are engaged in diverse res...

The medial temporal lobe (MTL) is essential for episodic memory encoding, as evidenced by memory deficits in patients with MTL damage. However, previous functional neuroimaging studies have either failed to show MTL activation during encoding or they did not differentiate between two MTL related processes: novelty assessment and episodic memory encoding. Furthermore, there is evidence that the ...

The precise functional role of the hippocampus in human episodic memory is an unresolved question though it has recently been suggested that distinct medial temporal lobe (MTL) regions are involved in encoding and retrieval operations respectively. For example, a recent meta-analysis of positron emission tomography (PET) literature has suggested a rostral-caudal functional division in the media...

The medial temporal lobe (MTL) is responsible for various mnemonic functions, such as association/conjunction memory. The lateral prefrontal cortex (LPFC) also plays crucial roles in mnemonic functions and memory-based cognitive behaviors, for example, decision-making. Therefore, it is considered that the MTL and LPFC connect with each other and cooperate for the control of cognitive behaviors....

Understanding the role of the medial temporal lobe (MTL) in learning and memory is an important problem in cognitive neuroscience. Memory and learning processes that depend on the function of the MTL and related diencephalic structures (e.g., the anterior and mediodorsal thalamic nuclei) are defined as declarative. We have studied the MTL activity as indicated by regional cerebral blood flow wi...

BACKGROUND Integration of information streams into a unitary representation is an important task of our cognitive system. Within working memory, the medial temporal lobe (MTL) has been conceptually linked to the maintenance of bound representations. In a previous fMRI study, we have shown that the MTL is indeed more active during working-memory maintenance of spatial associations as compared to...

The hippocampus and adjacent cortical structures in the medial temporal lobe (MTL) contribute to memory through interactions with distributed brain areas. Studies of monkey and rodent anatomy suggest that parallel pathways converge on distinct subregions of the MTL. To explore the cortical areas linked to subregions of the MTL in humans, we examined cortico-cortical and hippocampal-cortical cor...