نتایج جستجو برای: mir 103a 3p

تعداد نتایج: 49246  

2016
Teng Huang Li Yin Jing Wu Jia-Jia Gu Jian-Zhong Wu Dan Chen Hong-Liang Yu Kai Ding Nan Zhang Ming-Yu Du Lu-Xi Qian Zhi-Wei Lu Xia He

BACKGROUND Nasopharyngeal carcinoma (NPC) is among the most common squamous cell carcinoma in South China and Southeast Asia. Radiotherapy is the primary treatment for NPC. However, radioresistance acts as a significant factor that limits the efficacy of radiotherapy for NPC patients. Growing evidence supports that microRNAs (miRNAs) play an important role in radiation response. METHODS Real-...

Journal: :International journal of oncology 2015
Bo Fan Bao-Hua Jiao Feng-Shi Fan Sheng-Kui Lu Jian Song Cheng-Yong Guo Jian-Kai Yang Liang Yang

Gliomas are the most common and aggressive types of tumors in human brain, of which the prognosis remains dismal because of their biological behavior. The involvement of miRNAs in tumorigenesis of various kinds of cancers drives us to explore new miRNAs related to gliomas. We measured expression level of miR‑95‑3p by qRT-PCR in human glioma and non-neoplasm brain tissues and found that higher l...

2017
Shanshan Li Zhiyuan Jiang Lina Wen Guirong Feng Guoqiang Zhong

Previous studies have demonstrated that connexin40 (Cx40) remolding is involved in atrial fibrillation (AF). GJA5 encoding Cx40 is a potential target mRNA of microRNA-208a-3p (miR-208a-3p), as indicated by preliminary bioinformatics analyses. However, the exact effect of miR-208a-3p on Cx40 in human chronic AF has remained elusive. The present study demonstrated the role of miR-208a-3p in human...

2018
Fanfan Yi Yugui Hao Xiaoyi Chong Wei Zhong

The aim of the present study was to measure the expression of microRNA (miRNA)-506-3p in the peripheral blood of patients with hypertension and to determine the biological functions and mechanisms of action of miR-506-3p. A total of 61 patients with primary hypertension were included in the present study. Peripheral blood was collected from all patients, as well as 31 healthy subjects who were ...

2017
Xiaolin Tang Jiantao Lin Guanhai Wang Jianlin Lu

Dickkopf-1 (DKK1) is a powerful antagonist of canonical WNT signaling pathway, and is regarded as a biomarker for osteoporosis. Its expression is highly correlated with bone mass and osteoblasts maturation. In this study, mouse primary bone marrow cells and osteoblast cell lines were used. Luciferase reporter assay and western blotting methods were employed to validate if miRNA-433-3p epigeneti...

2014
Hong Ji Maoshan Chen David W. Greening Weifeng He Alin Rai Wenwei Zhang Richard J. Simpson Clark Chen

Secreted microRNAs (miRNAs) enclosed within extracellular vesicles (EVs) play a pivotal role in intercellular communication by regulating recipient cell gene expression and affecting target cell function. Here, we report the isolation of three distinct EV subtypes from the human colon carcinoma cell line LIM1863--shed microvesicles (sMVs) and two exosome populations (immunoaffinity isolated A33...

2017
Ling Yang Yongping Mu Hongwei Cui Yabing Liang Xiulan Su

MicroRNAs are short, single-stranded non-coding RNA molecules that function as regulators of tumor progression in various cancers, including glioma. The present study sought to investigate the biological functions of miR-9-3p in glioma progression. The results of a microRNA microarray indicated that microRNA-9-3p (miR-9-3p, miR-9*) is down-regulated in high-grade (grades III and IV) gliomas com...

2014
Guo Li Yunyun Wang Yong Liu Zhongwu Su Chao Liu Shuling Ren Tengbo Deng Donghai Huang Yongquan Tian Yuanzheng Qiu

Aberrant microRNA (miRNA) expression contributes to a series of malignant cancer behaviors, including radioresistance. Our previous study showed differential expression of miR-185-3p in post-radiation nasopharyngeal carcinoma (NPC) cells. To investigate the role of miR-185-3p in NPC radioresistance, CNE-2 and 5-8F cells were transfected with miR-185-3p mimic and miR-185-3p inhibitor, respective...

2017
Chunlin Jiang Jianting Long Baoxian Liu Ming Xu Wei Wang Xiaoyan Xie Xiaolin Wang Ming Kuang

BACKGROUND miR-500a-3p has been demonstrated to be involved in the development, progression and metastasis in several human cancers. Constitutive activation of JAK/STAT3 signaling pathway has been reported to play an important role in the development and progression of hepatocellular carcinoma (HCC).The purpose of this study was to determine the biological roles and clinical significance of miR...

Journal: :American journal of cancer research 2015
Jie Yu Qunyou Tan Bo Deng Chunshu Fang Di Qi Ruwen Wang

Growing evidence indicates that miR-520a was involved in the complement attack and migration of tumor cells, but nonetheless, the role of miR-520a-3p in non-small cell lung cancer (NSCLC) is not clear. Mitogen-activated protein kinase kinase kinase 2 (MAP3K2) is a kinase belonging to the serine/threonine protein kinase family. To develop potential therapy targeting MAP3K2, we studied the roles ...

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