Beta-caryophyllene (BC) is a chemical found in the essential oil of numerous plants which have shown various biomedical properties. In the present investigation we examined for the first time its genotoxic capacity in vivo by evaluating its potential to induce micronuclei in mouse. In a first assay we administered three doses of the compound once, and in a second assay, we administered three do...

background: in many studies, chemicals and natural materials were tested to reduce the harmful effects of radiation. it is known that famotidine and vitamin c reduce dna damage. objective: the aim of this study was to evaluate the radioprotective effect of vitamin c, cimetidine and famotidine on gamma-radiation-induced damage on mouse bone marrow.  methods: six-to-seven week male nmri mice (28 ...

Background: Genomic instability is one of primary causes for malignant cell transformation. In this study induced genomic instability expressed as micronuclei in breast cancer (BC) patients with different stages of the disease compared with their unaffected first degree relatives (FDR) and normal unrelated controls was investigated. Materials and Methods: The background and net micronucleus fre...

Objective(s)The aim of this study was to investigate the radioprotective effect of green tea against genotoxicity induced by gamma irradiation in cultured blood lymphocytes from 5 human volunteers.Materials and MethodsPeripheral blood samples were collected from volunteers before and 1, 3 and 5 hr after drinking a decoction 4 g green tea in 280 ml boiling water for 5 constitutive days with the ...

Background: Critical macromolecules of cells such as DNA are in exposure to damage of free radicals that induced from the interaction of ionizing radiation with biological systems. Selenium and vitamin-E are natural compounds that have been shown to be a direct free radical scavenger. The aim of this study was to investigate the radioprotective effect of selenium and vitamin-E separately and sy...

introduction: ionizing radiation induces various kinds of dna damage in which may lead to chromosomal aberrations (ca). inspite of growing importance in the risk assessment, the dose yield kinetics of ca and their implications for dose assessment are not well established in exposures to low level radiation. in the present study, cytochalasin-b blocked micronucleus assay and metaphase analysis w...

background: critical macromolecules of cells such as dna are in exposure to damage of free radicals that induced from the interaction of ionizing radiation with biological systems. selenium and vitamin-e are natural compounds that have been shown to be a direct free radical scavenger. the aim of this study was to investigate the radioprotective effect of selenium and vitamin-e separately and sy...