In this study, we report on the development of the first membrane-less, clog-free microfiltration platform for ultra-high throughput (up to 1000 mL/min) cell separation, using a massively-multiplexed array of inertial microfluidic cell sorting channels. Our developed system consists of multiple layer (10~20) of PDMS sheets with embossed microchannels (i.e., ~ 200 individual spirals) bonded toge...