Objective(s): This study aimed to investigate the glucose and lipid metabolism improving effect of the total flavonoids from Selaginella tamariscina (Beauv.) Spring (TFST) on db/db mice, and to study its mechanism of action.Materials and Methods: The db/db mice were divided into 5 groups: the normal group (NC), the diabetic group (DM), t...

Background: Previous studies demonstrated the effects of Intestinal microbiota composition on physiologic and pathologic processes in liver. Our aim was to study effect intestinal process liver regeneration (LR) using a model fecal transplantation (FMT) prior partial hepatectomy (PH). Methods: We used 70% PH mice induce LR. LR assessed mouse weight ratio, KI67 staining, RT-PCR for Cyclin D1. mi...

Introduction: Platelet alpha granule release was previously associated to development of liver dysfunction after resection. However, the relevance platelet degranulation in regeneration has not been elucidated thus far. Here we aimed investigate differences between mice lacking granules and wild type individuals partial hepatectomy (pHx). Method: Neurobeachin like 2 knock-out (Nbeal2-/-) functi...

Iron has been proposed as influencing the progression of liver disease in subjects with non-alcoholic fatty (NAFLD). We have previously shown that, Hfe−/− mouse model hemochromatosis, feeding a high-calorie diet (HCD) leads to increased injury. In this study we investigated whether an iron deficient/HCD mice influenced development NAFLD. Liver histology was assessed fed standard iron-containing...

Objective(s): The effects of low dose amphetamine on oxidative stress and rotenone-induced neurotoxicity and liver injury were examined in vivo in a mice model of Parkinson’s disease. Materials and Methods: Male mice were treated with rotenone (1.5 mg/kg, every other day for two weeks, subcutaneously). Mice received either the vehicle or...

Background Liver ischemia/reperfusion (I/R) injury is a complex and multifactorial pathophysiological process. It well recognized that the membrane permeability transition pore (mPTP) opening of mitochondria plays crucial role in cell death after I/R injury. Cyclophilin D (CypD) critical positive regulator mPTP. However, effect CypD on pathogenesis liver whether potential therapeutic target are...

Previous studies have shown that the clove essential oil concentration of 200 mg/kg did not present toxicity and histopathological changes in liver. Based on evidence presented this study, we decided to evaluate vivo ability a previously developed fermented dairy beverage, tested only vitro, which standard chemical preservative, potassium sorbate, was replaced by (2 μl/ml), be functional food. ...

Background: Diabetes produces free radicals and damages the liver. The aim of this study was to investigate the effects of Rosmarinus Officinalis leaf hydroalcoholic extract on histopathology and enzymes activity of liver in alloxan induced diabetic rats. Methods: In this study, 50 adult male Wistar rats weighing 200 to 250 grams, were divided randomly into 5 groups of 10; non-diabetic control...