The hypotensive efficacies of two vasodilators, hydralazine and minoxidil, were assessed as these drugs were used individually in combination with beta-adrenergic blockade and diuretics in 11 hypertensive patients in whom elevated blood pressure had not been adequately controlled previously by other antihypertensive therapy. Control supine blood pressure fell from 191/128 mm Hg on propranolol a...

Gallic acid and its derivatives are potential therapeutic agents for treating various oxidative stress mediated disorders. In the present study, we investigated the hepatoprotective effects of newly synthesized conjugated trimethylgallic acid (TMGA) esters against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Animals were pre-treated with TMGA esters at their respective doses for ...

Lung cancer is the leading cause of cancer- related death in the world today. Since the effective management of drug resistant lung cancer, and particularly non-small cell lung carcinomas is a major problem, attempts need to be made to identify new potential anticancer drugs that can kill non-small cell lung cancer cells efficiently. In the present study, a human non-small cell lung carcinoma N...

The nature of ultraluminous X-ray sources (ULXs) is presently unknown. A possible explanation is that they are accreting intermediate mass black holes (IBHs) that are fed by Roche lobe overflow from a tidally captured stellar companion. We show that a star can circularize around an IBH without being destroyed by tidal heating (in contrast to the case of M•>10 M⊙ massive black holes in galactic ...

Early diagnosis and treatment are crucial for the outcome of central nervous system (CNS) infections. In this study, we developed a multiplex PCR-Luminex assay for the simultaneous detection of five major pathogens, including Mycobacterium tuberculosis, Cryptococcus neoformans, Streptococcus pneumoniae, and herpes simplex virus types 1 and 2, which frequently cause CNS infections. Through the h...

OBJECTIVE: A rare case of LDD confirmed by biopsy is being reported. Review of the published cases shows that the disease usually manifests by the signs of increased intracranial pressure with inconstant cerebellar symptoms. MRI is the imaging modality of choice by now. As such, clinical problems after gross total or complete removal have not been reported so far, but herein we stress the impor...

Algorithms where offsprings (new search points) are generated according to the estimated probability model of the good parents are called the Probabilistic Model-Building Genetic Algorithms (PMBGAs). In this paper, a new model of PMBGA, Distributed PMBGA (DPMBGA), is proposed. In the DPMBGA, the correlation between the design variables is considered by PCA when the offsprings are generated. The...

INTRODUCTION Phenol and its derivatives are the most common poisonous compounds which are stable in aqueous media and lead to many health issues. In this study, application of the carbon resulted from pomegranate peel is investigated in removal of phenol by adsorption method. METHODS to perform this cross-sectional study, first, samples of phenol with concentrations of 10 to 100 mg/L were pre...

Trehalose is a nonreducing disaccharide of glucose that functions as a compatible solute in the stabilization of biological structures under abiotic stress in bacteria, fungi, and invertebrates. With the notable exception of the desiccation-tolerant "resurrection plants," trehalose is not thought to accumulate to detectable levels in most plants. We report here the regulated overexpression of E...

UNLABELLED Thyroid nodules are a common pathology of the thyroid gland. Thyroid fine-needle biopsy (FNB) is a technique used as the first step in the assessment of thyroid nodules. Some au- thors have demonstrated the superiority of nonaspiration compared with aspiration biopsy. AIM The objective was to assess whether there are significant differences between the two thyroid biopsy techniques...