A Vilsmeier salt supported on solid phase was prepared using piperazine bound to Merrifield resin. Piperazine was selected because it contains two secondary amines: one of the amines is protected upon binding to the resin, and the second was formylated to give resin-1-N-piperazine-4-N-carboxaldehyde (9). Activation of the formamide with either bis(trichloromethyl)carbonate (BTC) or POCl(3) affo...

Repeat transects of full-depth density and velocity are used to quantify generation and radiation of the semidiurnal internal tide from Kaena Ridge, Hawaii. A 20-km-long transect was sampled every 3 h using expendable current profilers and the absolute velocity profiler. Phase and amplitude of the baroclinic velocity, pressure, and vertical displacement were computed, as was the energy flux. La...

Precision in orthodontic diagnosis can increase the chance of therapeutic success. The objective of this study was to describe the development of a computerized system (prototype), created from a printed table of the Cranial Facial Analysis and Total Dentition Space Analysis with Difficulty Index--Tweed-Merrifield Analysis--in order to aid orthodontic diagnosis. The analysis was transposed from...

Since the introduction of SPPS by Merrifield in the 60s, peptide chemists have considered the possibility of preparing large proteins. The introduction of native chemical ligation in the 90s and then of expressed protein ligation have opened the way to the preparation of synthetic proteins without size limitations. This review focuses on semi-synthetic strategies useful to prepare proteins deco...

The chloromethylation of activated carbon is described. Chloromethylation was found to produce a carbon derivative with a surface area of 1310 m(2)/g and no significant change in the pore structure. The product was found to contain ~1.5 mmole of -CH(2)Cl groups per g of material, similar to the functional density reported in the original Merrifield resin synthesis. Displacement of the benzylic ...

Earlier studies have indicated that Eurasian milfoil is not as large a problem in Otsego Lake as in other water bodies (Minor, 1997). It has been hypothesized that Acentria ephemerella. present in Otsego Lake, controls Eurasian milfoil (Merrifield and Hannan, 1988). In its larval stage Acentria grazes on milfoil, hindering its growth. In the summer of 1997 Miner (1998) studied meroplankton foun...

INTRODUCTION The esthetic balance of the face results from harmonic and symmetrical facial proportions. The literature describes several methods for lower-third facial analysis, but lacks a simple and practical method. OBJECTIVE To review the methods of analysis of the ideal projections of the chin based on soft tissues, showing the advantages and disadvantages of each. METHODS Literature r...