Lumazine synthase and riboflavin synthase catalyze the last two steps in the biosynthesis of riboflavin. To obtain structural and mechanistic probes of these two enzymes, as well as inhibitors of potential value as antibiotics, a sulfur analogue of the pyrimidine substrate of the lumazine synthase-catalyzed reaction and product of the riboflavin synthase-catalyzed reaction was designed. Facile ...

Correction for ‘Engineering strategies rational polyketide synthase design’ by Maja Klaus et al., Nat. Prod. Rep., 2018, 35, 1070–1081, DOI: 10.1039/C8NP00030A.

Marjinal arazi koşullarında yürütülen bu çalışmada 2 farklı ekim zamanının (sonbahar ve ilkbahar) Tıbbi Nane (Mentha × piperita L. var. Mitcham)’nin verim kalitesi üzerine etkileri araştırılmıştır. Deneme Doğu Akdeniz’in Çukurova Bölgesinde tesadüf blokları deneme desenine göre üç tekrarlamalı olarak gerçekleştirilmiştir. Sonuçlara en yüksek bitki boyu (43 cm), taze herba verimi (12763 kg ha-1)...

objective(s): nucleus raphe magnus (nrm) that is involved in the regulation of body temperature contains nitric oxide (no) synthase. considering the effect of no on skin blood flow control, in this study, we assessed its thermoregulatory role within the raphe magnus. materials and methods: to this end, tail blood flow of male wistar rats was measured by laser doppler following the induction of ...

CDP-diacylglycerol (CDP-DG) is an important branchpoint intermediate in eucaryotic phospholipid biosynthesis and could be a key regulatory site in phospholipid metabolism. Therefore, we examined the effects of growth phase, phospholipid precursors, and the disruption of phosphatidylcholine (PC) synthesis on the membrane-associated phospholipid biosynthetic enzymes CDP-DG synthase, phosphatidylg...

Anthranilate synthase (AS), aminodeoxychorismate synthase (ADCS), isochorismate synthase (IS), and salicylate synthase (SS) are structurally homologous chorismate-utilizing enzymes that carry out the first committed step in the formation of tryptophan, folate, and the siderophores enterobactin and mycobactin, respectively. Each enzyme catalyzes a nucleophilic substitution reaction, but IS and S...