نتایج جستجو برای: mendelian
تعداد نتایج: 7468 فیلتر نتایج به سال:
Mendelian randomization is an epidemiological approach to making causal inferences using observational data. It makes use of the natural that occurs in generation individual’s genetic makeup a way analogous study design randomized controlled trial and uses instrumental variable analysis where variant(s) are instrument (analogous random allocation treatment group trial). As with any variable, th...
BACKGROUND Increased circulating plasma urate concentration is associated with an increased risk of coronary heart disease, but the extent of any causative effect of urate on risk of coronary heart disease is still unclear. In this study, we aimed to clarify any causal role of urate on coronary heart disease risk using Mendelian randomisation analysis. METHODS We first did a fixed-effects met...
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